Abstract | ETHNOPHARMACOLOGICAL RELEVANCE: MATERIALS AND METHODS: Sixty adult male Sprague-Dawley rats were randomly divided into 3 groups, each containing 20 rats. Rats in the control group underwent a sham operation of the left testis. In the torsion-detorsion group, the left testis was rotated 720° for 2h. Rats in the treatment group received the same surgical procedure as the torsion-detorsion group, but Psoralea corylifolia was administered orally. Bilateral orchiectomy was performed on half of the rats in each experimental group at 4h after detorsion for measurement of malondialdehyde which is an indicator of intratesticular reactive oxygen species content. Orchiectomy was performed on the remaining rats at 3 months after detorsion for analysis of testicular CREMτ expression and spermatogenesis. RESULTS: Unilateral testicular torsion-detorsion caused a significant increase in malondialdehyde level and caused significant decreases in CREMτ expression and spermatogenesis in ipsilateral testes. Psoralea corylifolia treatment significantly decreased malondialdehyde level and significantly increased CREMτ expression and spermatogenesis in ipsilateral testes, compared with torsion-detorsion group. CONCLUSIONS: These results suggest that Psoralea corylifolia may protect testicular spermatogenesis by enhancing CREMτ expression by scavenging reactive oxygen species.
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Authors | Si-Ming Wei, Zhi-Zhong Yan, Jian Zhou |
Journal | Journal of ethnopharmacology
(J Ethnopharmacol)
Vol. 137
Issue 1
Pg. 568-74
(Sep 01 2011)
ISSN: 1872-7573 [Electronic] Ireland |
PMID | 21704691
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Copyright | Copyright © 2011 Elsevier Ireland Ltd. All rights reserved. |
Chemical References |
- Crem protein, rat
- Drugs, Chinese Herbal
- Free Radical Scavengers
- Cyclic AMP Response Element Modulator
- Malondialdehyde
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Topics |
- Animals
- Cyclic AMP Response Element Modulator
(metabolism)
- Cytoprotection
- Disease Models, Animal
- Drugs, Chinese Herbal
(isolation & purification, pharmacology)
- Free Radical Scavengers
(isolation & purification, pharmacology)
- Fruit
- Male
- Malondialdehyde
(metabolism)
- Plants, Medicinal
- Psoralea
(chemistry)
- Rats
- Rats, Sprague-Dawley
- Reperfusion Injury
(etiology, metabolism, physiopathology, prevention & control)
- Spermatic Cord Torsion
(complications, drug therapy, metabolism, physiopathology)
- Spermatogenesis
(drug effects)
- Testis
(blood supply, drug effects, metabolism, physiopathology)
- Time Factors
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