[Pharmacology of preventive and therapeutic drugs for NSAIDs ulcers in the gastrointestinal tract].

Abstract

NSAIDs have been associated with gastrointestinal (GI) toxicity. Proton pump inhibitors (PPIs) may be the first line in the treatment as well as in the prevention of NSAIDs-induced ulcers. Although there are no definite differences among three PPIs(omeprazole, lansoprazole, and rabeprazole) in the clinical field, it should be considered to inhibit gastric acid secretion rapidly and strongly in case of the treatment with acute gastric ulcer in patients who should be continued to be NSAIDs treatment. Recently, the serious problem of NSAID-induced small intestinal damage has become a topic of great interest to gastroenterologists, since capsule endoscopy and balloon enteroscopy are available for the detection of small intestinal lesions. Further understanding of the pathogenesis of NSAID-induced intestinal ulcers is important to enable the development of novel and effective preventive strategies.

• Authors: Yuji Naito, Tomohisa Takagi, Toshikazu Yoshikawa
• Journal: Nihon rinsho. Japanese journal of clinical medicine (Nihon Rinsho) Vol. 69 Issue 6 Pg. 1007-15 (Jun 2011) ISSN: 0047-1852 [Print] Japan
• PMID: 21688620 (Publication Type: English Abstract, Journal Article, Review)

Chemical References

• Anti-Inflammatory Agents, Non-Steroidal
• Proton Pump Inhibitors

Topics

• Anti-Inflammatory Agents, Non-Steroidal (adverse effects)
• Humans
• Peptic Ulcer (chemically induced, drug therapy)
• Proton Pump Inhibitors (therapeutic use)