Milestones in neuroimaging.

Abstract

In the last 25 years there have been enormous advances in brain imaging. In addition to utility in diagnosis, these have led to novel insights into the pathogenesis of basal ganglia disease and the role of dopamine and the basal ganglia in normal health. The authors review highlights of this work, with a focus on advances in Parkinson's disease, the dystonias, Huntington's disease, and the role of dopamine in cognition and reward signaling. Emerging areas for future development include studies of functional connectivity, the analysis of default mode networks, studies of novel neurochemical pathways, methods to study disease pathogenesis, and the application of imaging techniques to investigate animal models of disease.

• Authors: A Jon Stoessl, David J Brooks, David Eidelberg
• Journal: Movement disorders : official journal of the Movement Disorder Society (Mov Disord) Vol. 26 Issue 6 Pg. 868-978 (May 2011) ISSN: 1531-8257 [Electronic] United States
• PMID: 21626537 (Publication Type: Historical Article, Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't)
• Copyright: Copyright © 2011 Movement Disorder Society.

Topics

• Brain (pathology)
• Diagnostic Imaging (history, methods, trends)
• History, 20th Century
• History, 21st Century
• Humans
• Movement Disorders (diagnosis)