Antiulcerative effect of dexmedetomidine on indomethacin-induced gastric ulcer in rats.

Abstract

A gastroprotective effect occurs when α(2) receptors are innervated. The dextro isomer of medetomidine, dexmedetomidine, is a highly selective α(2)-adrenoreceptor agonist. The aim of this study was to investigate whether dexmedetomidine has an antiulcerative effect and to show whether the antiulcer mechanism of dexmedetomidine is linked with oxidant/antioxidant parameters. The antiulcerative effect of dexmedetomidine was studied in an indomethacin-induced ulcer model, and some oxidant/antioxidant parameters were measured in these gastric tissues. Whereas the average ulcerous areas for the groups that received 10, 25, 50, and 100 μg/kg dexmedetomidine doses were 29 ± 4.2, 8 ± 2.1, 0 ± 0 and 0 ± 0 mm(2), respectively, the ulcerous area was 52.1 ± 4.5 mm(2) in the indomethacin control group and 0.5 ± 0.2 mm(2) in the famotidine group. In conclusion, the α(2)-adrenoreceptor agonist dexmedetomidine showed a significant antiulcerative effect in rat gastric tissue at all doses. This antiulcerative effect is stronger with increasing dosage; at the 50 and 100 μg/kg doses, no ulcerous areas were observed. In light of these results, we conclude that there is a correlation between antiulcer mechanisms and α(2)-receptor activation. In rats given dexmedetomidine, all of the investigated antioxidant parameters increased, except for catalase (CAT). Conversely, aside from myeloperoxidase (MPO), all oxidant parameters decreased. Therefore, oxidant/antioxidant parameters play a role in the antiulcer mechanism of dexmedetomidine.

• Authors: Beyzagul Polat, Yavuz Albayrak, Bahadír Suleyman, Hakan Dursun, Fehmi Odabasoglu, Murat Yigiter, Zekai Halici, Halis Suleyman
• Journal: Pharmacological reports : PR (Pharmacol Rep) Vol. 63 Issue 2 Pg. 518-26 ( 2011) ISSN: 2299-5684 [Electronic] Switzerland
• PMID: 21602607 (Publication Type: Comparative Study, Journal Article)

Chemical References

• Adrenergic alpha-2 Receptor Agonists
• Anti-Inflammatory Agents, Non-Steroidal
• Anti-Ulcer Agents
• Antioxidants
• Oxidants
• Famotidine
• Dexmedetomidine
• Indomethacin

Topics

• Adrenergic alpha-2 Receptor Agonists (administration & dosage, pharmacology)
• Animals
• Anti-Inflammatory Agents, Non-Steroidal (toxicity)
• Anti-Ulcer Agents (administration & dosage, pharmacology)
• Antioxidants (metabolism)
• Dexmedetomidine (administration & dosage, pharmacology)
• Disease Models, Animal
• Dose-Response Relationship, Drug
• Famotidine (pharmacology)
• Indomethacin (toxicity)
• Male
• Oxidants (metabolism)
• Rats
• Rats, Wistar
• Stomach Ulcer (chemically induced, drug therapy, pathology)