Carcinoma infection and immune systems of Ehrlich ascites carcinoma-bearing mice treated with structurally similar sulfonium compounds.

Abstract

The effects of intraperitoneal administration of dimethylsulfonioacetate (DMSA), dimethlsulfoniopropionate (DMSP), and methylmethionine (MeMet) solutions (10 mM each) on the body weights and the hematological parameters (red and white blood cells) of Ehrlich ascites carcinoma (EAC)-bearing mice were examined for up to 10 d. Body weights significantly increased in the EAC-bearing mice treated with and without MeMet in contrast to those with DMSA and DMSP. This increase was attributed to the increased amounts of ascitic fluid. EAC-bearing mice with and without MeMet both showed abnormal values of hematological parameters, while those with DMSA and DMSP exhibited almost normal levels on the 10th day.

• Authors: Kenji Nakajima, Yoshiki Nakajima
• Journal: Bioscience, biotechnology, and biochemistry (Biosci Biotechnol Biochem) Vol. 75 Issue 4 Pg. 808-11 ( 2011) ISSN: 1347-6947 [Electronic] England
• PMID: 21512215 (Publication Type: Journal Article)

Chemical References

• Antineoplastic Agents
• Sulfonium Compounds

Topics

• Animals
• Antineoplastic Agents (chemistry, pharmacology, therapeutic use)
• Carcinoma, Ehrlich Tumor (drug therapy, immunology, pathology)
• Immune System (drug effects)
• Male
• Mice
• Sulfonium Compounds (chemistry, pharmacology, therapeutic use)