Podoplanin expression in adamantinoma of long bones and osteofibrous dysplasia.

Abstract	Adamantinoma of long bones (ALB) and osteofibrous dysplasia (OFD) are rare osteolytic bone tumours that principally arise in the tibia. Both ALB and OFD contain epithelial and stromal elements, as well as areas of fibro-osseous proliferation. We assessed expression of podoplanin, a glycoprotein found in osteocytes, in OFD and ALB as well as in fibrous dysplasia and metastatic cancer. Forty-two cases of ALB and OFD, 20 cases of fibrous dysplasia and 20 cases of metastatic carcinoma to bone were stained by immunohistochemistry for expression of podoplanin, epithelial (cytokeratin, epithelial membrane antigen) and vascular (CD34, LYVE-1) markers. Podoplanin was expressed in epithelial cells and tumour glands in ALB as well as in scattered intertrabecular stromal cells in both ALB and OFD. Podoplanin was not expressed by intertrabecular stromal cells in fibrous dysplasia or in metastatic adenocarcinoma. Podoplanin was expressed by osteocytes but not osteoblasts of woven and lamellar bone trabeculae in ALB, OFD, fibrous dysplasia and skeletal metastases. The finding of a common osteocyte marker in OFD/ALB stromal cells is in keeping with a close histogenetic relationship between OFD and ALB; this may reflect the prominence of fibro-osseous proliferation in these tumours. The expression of podoplanin in an osteolytic tumour of the tibia may be useful as a diagnostic discriminant in distinguishing OFD from fibrous dysplasia and ALB from metastatic adenocarcinoma.
Authors	Takeshi G Kashima, Arunthati Dongre, Adrienne M Flanagan, Pancras C W Hogendoorn, Richard Taylor, Nicholas A Athanasou
Journal	Virchows Archiv : an international journal of pathology (Virchows Arch) Vol. 459 Issue 1 Pg. 41-6 (Jul 2011) ISSN: 1432-2307 [Electronic] Germany
PMID	21499851 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References	Biomarkers, Tumor Membrane Glycoproteins PDPN protein, human
Topics	Adamantinoma (metabolism, pathology) Adolescent Adult Biomarkers, Tumor (metabolism) Bone Neoplasms (metabolism, pathology) Child Child, Preschool Fibrous Dysplasia of Bone (metabolism, pathology) Humans Membrane Glycoproteins (metabolism) Middle Aged Young Adult

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.

Realize the full power of the drug-disease research graph!