Abstract | AIMS:
Epithelial cell adhesion molecule ( EpCAM) is a cell surface protein with oncogenic features that is expressed on healthy human epithelia and corresponding malignant tumours. EpCAM expression frequently correlates with more aggressive tumour behaviour and new EpCAM-specific therapeutic agents have recently been approved for clinical use in patients with cancer. However, no consensus exists on how and when to evaluate EpCAM expression in patients with cancer. MATERIAL AND METHODS:
EpCAM expression was assessed by a well-established immunohistochemical staining protocol in 2291 primary tumour tissues and in 108 metastases using the EpCAM-specific antibody clone VU1D9. A total immunostaining score was calculated as the product of a proportion score and an intensity score. Four expression subgroups (no, weak, moderate and intense) were defined. As described previously, the term ' EpCAM overexpression' was reserved for tissues showing a total immunostaining score >4. RESULTS: CONCLUSION:
|
Authors | Gilbert Spizzo, Dominic Fong, Martin Wurm, Christian Ensinger, Peter Obrist, Carina Hofer, Guido Mazzoleni, Guenther Gastl, Philip Went |
Journal | Journal of clinical pathology
(J Clin Pathol)
Vol. 64
Issue 5
Pg. 415-20
(May 2011)
ISSN: 1472-4146 [Electronic] England |
PMID | 21415054
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
|
Chemical References |
- Antigens, Neoplasm
- Biomarkers, Tumor
- Cell Adhesion Molecules
- Epithelial Cell Adhesion Molecule
|
Topics |
- Antigens, Neoplasm
(metabolism)
- Biomarkers, Tumor
(metabolism)
- Breast Neoplasms
(metabolism)
- Carcinoma
(classification, metabolism)
- Cell Adhesion Molecules
(metabolism)
- Cell Line, Tumor
- Digestive System Neoplasms
(metabolism)
- Epithelial Cell Adhesion Molecule
- Female
- Gastrointestinal Neoplasms
(metabolism)
- Humans
- Immunohistochemistry
- Neoplasm Metastasis
- Neoplasms
(classification, metabolism)
- Respiratory Tract Neoplasms
(metabolism)
- Urogenital Neoplasms
(metabolism)
|