Pure akinesia with low myocardial metaiodobenzylguanidine uptake.

Abstract

The objective of this study was to delineate the clinical features of patients with pure akinesia and a low heart versus mediastinum ratio below 2.0 in the delayed images of myocardial metaiodobenzylguanidine scintigraphy, a marker for the clinical diagnosis of Lewy body diseases. A total of 13 patients was enrolled. The clinical features of the patients were uniformly elderly (mean age, 73.7 years), a male gender preponderance (10 men and 3 women), relatively mild motor disability (mean Hoehn Yahr grade 2.4) without laterality, festinating gait (77%) and loss of postural reflex (69%), which were the most common; also observed were fair levodopa responses (70%), cognitive dysfunction in some (23%), common autonomic dysfunction (urinary urgency and frequency, 85%; constipation, 77%; and postural hypotension, 38%) and common occipital hypoperfusion (62%). These features may facilitate the clinical differential diagnosis of these patients from patients with pure akinesia due to progressive supranuclear palsy.

• Authors: Fuyuki Tateno, Ryuji Sakakibara, Masahiko Kishi, Emina Ogawa
• Journal: Parkinsonism & related disorders (Parkinsonism Relat Disord) Vol. 17 Issue 5 Pg. 357-9 (Jun 2011) ISSN: 1873-5126 [Electronic] England
• PMID: 21376652 (Publication Type: Journal Article)
• Copyright: Copyright © 2011 Elsevier Ltd. All rights reserved.

Chemical References

• 3-Iodobenzylguanidine

Topics

• 3-Iodobenzylguanidine (metabolism)
• Aged
• Aged, 80 and over
• Female
• Heart (diagnostic imaging)
• Humans
• Male
• Mental Status Schedule
• Movement Disorders (diagnostic imaging, pathology)
• Tomography, Emission-Computed, Single-Photon (methods)