Orthostatic Hypotension (Postural Hypotension)

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1667 relevant articles (108 outcomes, 144 trials/studies) found for this Disease

Description: A significant drop in BLOOD PRESSURE after assuming a standing position. Orthostatic hypotension is a finding, and defined as a 20-mm Hg decrease in systolic pressure or a 10-mm Hg decrease in diastolic pressure 3 minutes after the person has risen from supine to standing. Symptoms generally include DIZZINESS, blurred vision, and SYNCOPE.

Also Known As:

Postural Hypotension; Hypotension, Orthostatic; Hypotension, Postural

Relationship Network

Disease Context: Research Results

Nervous System Diseases: 3643

Autonomic Nervous System Diseases: 17

Primary Dysautonomias: 155

Orthostatic Intolerance: 184

Orthostatic Hypotension: 1667

Cardiovascular Diseases: 20552

Vascular Diseases: 7633

Hypotension: 15560

Orthostatic Hypotension: 1667

Related Diseases

1.	Hypertension (High Blood Pressure)
2.	Hypotension (Low Blood Pressure)
3.	Anemia
4.	Dizziness (Lightheadedness)
5.	Nausea

Experts

1.	Meck, Janice V: 5 articles (04/2006 - 01/2003)
2.	Goldstein, David S: 4 articles (09/2008 - 06/2003)
3.	Holmes, Courtney: 4 articles (09/2008 - 06/2003)
4.	Waters, Wendy W: 3 articles (04/2006 - 06/2004)
5.	Platts, Steven H: 3 articles (04/2006 - 06/2004)
6.	Sharabi, Yehonatan: 2 articles (09/2008 - 12/2005)
7.	Pechnik, Sandra: 2 articles (09/2008 - 12/2005)
8.	Kaufmann, Horacio: 2 articles (03/2008 - 08/2003)
9.	Opfer-Gehrking, Tonette L: 2 articles (04/2006 - 02/2005)
10.	Singer, Wolfgang: 2 articles (04/2006 - 02/2005)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Orthostatic Hypotension:

1.	Midodrine (Midon)FDA LinkGeneric 05/01/1994 - "The efficacy of Midodrine in successfully treating orthostatic hypotension secondary to autonomic failure has been shown in clinical trials. " 06/01/1988 - "Autonomic cardiovascular reflexes were significantly more impaired in patients of group II than in patients of group I. We conclude that midodrine is effective in the treatment of orthostatic hypotension only in those patients with significant preservation of autonomic reflexes. " 07/01/1993 - "CONCLUSION: We conclude that midodrine is an effective and well-tolerated treatment for moderate-to-severe orthostatic hypotension associated with autonomic failure." 06/01/1993 - "Therefore, midodrine is an effective and safe agent for the treatment of neurogenic orthostatic hypotension." 08/06/1997 - "Efficacy of midodrine for neurogenic orthostatic hypotension." Order ALL the reference details at left...
2.	FludrocortisoneIBA 07/01/1990 - "The orthostatic hypotension of the patient as effectively treated with fludrocortisone. " 02/01/2000 - "The aim of the present study was to examine whether the improvement in orthostatic blood pressure during combined treatment with low-dose fludrocortisone and nocturnal head-up tilt in patients with neurogenic orthostatic hypotension can be attributed to expansion of plasma volume or to increased total peripheral resistance. " 08/01/2005 - "Since only fludrocortisone negatively altered gene expression, we assessed fludrocortisone's efficacy in treating postural hypotension, and its effect on survival and secondary long-term FD problems. " 02/01/2000 - "The improvement in upright blood pressure in orthostatic hypotension during treatment with fludrocortisone and nocturnal head-up sleeping is the result of a reduction in the orthostatic decrease in cardiac output. " 07/01/1987 - "Treatment of orthostatic hypotension with fludrocortisone acetate relieved these symptoms. " Order ALL the reference details at left...
3.	DroxidopaIBA 03/01/1999 - "The enhanced responses of these vasoactive mediators by L-threo-DOPS during head-up tilt may contribute to the improvement in orthostatic hypotension in patients with MSA." 08/01/2001 - "Following a one-week run-in, patients (26 MSA; 6 PAF) with symptomatic orthostatic hypotension received increasing doses of L-threo-DOPS (100, 200 and 300 mg, twice daily) in an open, dose-ranging study. " 03/01/2008 - "L-dihydroxyphenylserine (Droxidopa) in the treatment of orthostatic hypotension: the European experience." 03/01/2008 - "L-dihydroxyphenylserine (Droxidopa): a new therapy for neurogenic orthostatic hypotension: the US experience." 08/01/2001 - "The dosage of 300 mg twice daily L-threo-DOPS seemed to offer the most effective control of symptomatic orthostatic hypotension in MSA and PAF." Order ALL the reference details at left...
4.	ErythropoietinIBA 12/01/1997 - "The objective of this study was to determine the alteration of autonomic control during erythropoietin therapy in a patient with severe autonomic failure and severe symptomatic orthostatic hypotension, evaluated by spectral analysis of heart rate variability. " 01/01/2003 - "Successful treatment of severe orthostatic hypotension with erythropoietin." 10/01/2002 - "Additional options for treatment of orthostatic hypotension include erythropoietin and, surprisingly, water. " 06/01/2001 - "Erythropoietin treatment of postural hypotension in anemic type 1 diabetic patients with autonomic neuropathy: a case study of four patients." 12/01/1996 - "Erythropoietin treatment for postural hypotension from autonomic dysfunction." Order ALL the reference details at left...
5.	Norepinephrine (Noradrenaline)FDA LinkGeneric 01/01/2001 - "OBJECTIVES: This study was designed to establish a patient-controlled, ambulatory norepinephrine treatment of refractory orthostatic hypotension due to primary autonomic failure. " 06/01/2004 - "Many astronauts exhibit post-spaceflight orthostatic hypotension due to inadequate norepinephrine release when in an upright posture. " 12/01/2003 - "The hallmark of both central and peripheral causes of neurogenic orthostatic hypotension is the failure to release norepinephrine appropriately upon standing. " 08/12/2003 - "Norepinephrine precursor therapy in neurogenic orthostatic hypotension." 04/23/2002 - "Supine plasma norepinephrine was lower in patients with than in those without orthostatic hypotension (1.40 +/- 0.15 vs 2.32 +/- 0.26 nmol/L, p = 0.005). " Order ALL the reference details at left...
6.	Levodopa (L Dopa)FDA LinkGeneric 01/01/1993 - "This study was undertaken to clarify the mechanism of orthostatic hypotension, one of the side effects frequently encountered after administration of levodopa (L-dopa). " 07/01/2007 - "In contrast, levodopa significantly lowered BP and HR at rest and enhanced orthostatic hypotension. " 12/01/2005 - "Neurocirculatory abnormalities underlying orthostatic hypotension might reflect levodopa treatment. " 06/01/1995 - "During his hospital stay, he developed episodes of oculogyric crisis during peak dose of levodopa, and orthostatic hypotension. " 01/01/1993 - "These results suggest that peripheral, rather than central, mechanisms are involved in L-dopa-induced orthostatic hypotension." Order ALL the reference details at left...
7.	Octreotide (Sandostatin)FDA LinkGeneric 10/01/1995 - "4. After octreotide, although the rate of blood pressure recovery was similar post-exercise, the levels of blood pressure were higher than in the non-treatment phase and postural hypotension was improved before and after exercise. " 02/01/1992 - "Lack of efficacy of octreotide in the long term treatment of orthostatic hypotension." 01/01/1999 - "Octreotide for orthostatic hypotension." 01/01/1997 - "Effects of octreotide on experimental neurogenic orthostatic hypotension in anaesthetized dogs." 08/01/1996 - "These results suggest that 1) this experimental model of orthostatic hypotension in SAD dogs is reproductible and can be used to investigate the pharmacological effects of antihypotensive drugs, 2) cardiovascular and biochemical characteristics of the SAD model are similar to those observed in MSA and 3) octreotide, in these experimental conditions, is not able to correct the BP fall during head-up tilt test." Order ALL the reference details at left...
8.	SodiumIBA 02/01/2002 - "We conclude that high sodium intake is an effective treatment for orthostatic hypotension in combination with vasoactive drugs." 02/01/2002 - "Efficacy of high sodium intake in a boy with instantaneous orthostatic hypotension." 09/01/1981 - "This study indicated that long-term converting enzyme inhibition and sodium depletion were safe and did not appreciably blunt the cardiovascular reflexes responsible for prevention of orthostatic hypotension." 08/01/2006 - "Sodium paradoxically reduces the gastropressor response in patients with orthostatic hypotension." 04/01/2001 - "Orthostatic hypotension may complicate very-low-calorie protein diets because of sodium depletion and depressed sympathetic nervous system activity. " Order ALL the reference details at left...
9.	Dihydroergotamine (Agit)FDA LinkGeneric 12/01/1981 - "The efficacy of dihydroergotamine (DHE-45) in the treatment of orthostatic hypotension due to deficient circulatory reflexes was investigated in 10 patients. " 05/09/1987 - "A cooperative study of dihydroergotamine in the treatment of severe postural hypotension was conducted in 16 patients. " 01/01/1992 - "Its effect on the uterine arterial circulation is unstudied and yet dihydroergotamine is widely used to treat postural hypotension in pregnant and nonpregnant women. " 07/03/1989 - "[Dihydroergotamine and orthostatic hypotension in elective hip surgery]" 06/01/1987 - "Orthostatic hypotension is best treated with physical measures, pharmacologically with 9-alpha-fluorohydrocortisone and dihydroergotamine mesylate. " Order ALL the reference details at left...
10.	Propranolol (Inderal)FDA LinkGeneric 11/01/1981 - "Improvement in symptoms and correction of the orthostatic hypotension were demonstrated in seven patients after beta-adrenergic blockade with propranolol. " 01/01/1977 - "The studies suggest that propranolol is a useful drug in selected patients with severe idiopathic orthostatic hypotension." 10/01/1984 - "[Therapeutic effect of propranolol in patients with orthostatic hypotension]" 11/01/1983 - "These data suggest that when orthostatic hypotension is secondary to failure in peripheral vasoconstriction, propranolol may act beneficially. " 11/01/1983 - "As a consequence, propranolol failed to control orthostatic hypotension in this patient. " Order ALL the reference details at left...

Therapies and Procedures

1.	Renal Dialysis (Hemodialysis) 04/01/2002 - "Orthostatic hypotension is one of the major factors interfering with everyday activities in hemodialysis patients, but there has been no effective agent for treating it. " 04/01/2002 - "These findings indicate that L-DOPS taken before hemodialysis prevents orthostatic hypotension in patients undergoing hemodialysis, and is also effective for the interdialytic symptoms related to orthostatic hypotension." 04/01/2002 - "In order to clarify the clinical effects of L-threo-3,4-dihydroxyphenylserine (L-DOPS) on orthostatic hypotension of hemodialysis patients, we conducted a randomized, double-blind comparative trial. " 11/01/2006 - "Treatment of post-dialytic orthostatic hypotension with an inflatable abdominal band in hemodialysis patients." 07/01/2002 - "Effects of L-threo-3,4-dihydroxyphenylserine on orthostatic hypotension in hemodialysis patients." Order ALL the reference details at left...
2.	Bed Rest (Bedrest) 07/01/2000 - "The purpose of the present study is to examine the changes in the arterial baroreflex control of muscle sympathetic nerve activity (MSNA) after head-down bed rest (HDBR), in relation to orthostatic hypotension after HDBR. " 01/01/1991 - " In the first study, exposure to simulated microgravity (6 degrees headdown bedrest) reduced the sensitivity and buffer capacity of the vagal baroreceptor-cardiac reflex mechanisms and this impaired baroreflex function was associated with orthostatic hypotension. " 07/01/2007 - "INTRODUCTION: The preservation of cerebral blood flow with orthostatic hypotension (e.g., following prolonged bed rest or microgravity exposure) is vital for the attenuation of symptoms and the maintenance of consciousness. " 02/01/2005 - "Fluid loading at the end of bed rest restored plasma volume and resulted in the absence of post-bed-rest orthostatic hypotension and changes in supine hemodynamic and endocrine variables. " 09/01/2004 - "She had persistent postural hypotension lasting for about 24 hours requiring bed rest and was discharged about 36 hours after the procedure, without any adverse sequelae. " Order ALL the reference details at left...
3.	Drug Therapy (Chemotherapy) 09/01/1994 - "The objectives of this study were to determine the prevalence of, and factors associated with, postural hypotension (PH) in elderly treated hypertensive subjects, to examine the 24h BP profile in those subjects with and without PH and to determine the effects of antihypertensive treatment withdrawal on the prevalence and symptoms of PH. Eighty-six subjects (mean age +/- standard deviation 76 +/- 6 years) on antihypertensive drug therapy for > 6 months had three clinic BP measurements taken in supine and standing positions followed by 24h ambulatory BP monitoring. " 04/01/2008 - "Drug therapy should be initiated with lower doses of medication with a special concern about orthostatic hypotension." 09/01/1991 - "Drug therapy should be initiated with lower doses of medication with special concern about orthostatic hypotension. " 10/01/1988 - "Although the physiologic basis for this therapeutic response is unclear, our results indicate that tilt table conditioning may be an important adjunct to drug therapy in patients with severe orthostatic hypotension." 01/26/1987 - "Drug therapy should be initiated with lower doses of medication with a special concern about orthostatic hypotension." Order ALL the reference details at left...
4.	Lower Body Negative Pressure 09/01/2006 - "The objective of this study was to evaluate the use of LBNP for detecting drug-induced changes in susceptibility to orthostatic hypotension in conscious monkeys (Macaca fascicularis). " 09/01/2006 - "INTRODUCTION: Methods most commonly used for detecting susceptibility to orthostatic hypotension in humans include head-up tilt and the application of lower body negative pressure (LBNP). " 09/01/2006 - "A model of orthostatic hypotension in the conscious monkey using lower body negative pressure." 01/01/1998 - "BACKGROUND: Endurance-trained males may be more prone to orthostatic hypotension than untrained subjects and this is reflected in differences in their cardiovascular responses to lower body negative pressure (LBNP). " 05/01/1994 - "Thus, there are numerous drugs that, in combination with mechanical techniques, including lower body negative pressure to elevate transmural pressure, could be studied to treat orthostatic hypotension after space flight." Order ALL the reference details at left...
5.	Biofeedback (Psychology) (Biofeedback) 09/01/1996 - "OBJECTIVE: To evaluate the efficacy of various physical countermaneuvers in reducing orthostatic hypotension and its associated symptoms and to assess the efficacy of biofeedback training in enhancing the effectiveness of physical countermaneuvers. " 09/01/1996 - "CONCLUSION: Physical countermaneuvers are efficacious in reducing orthostatic hypotension, can be augmented by use of biofeedback, and may significantly improve the functional outcome. " 09/01/1996 - "Role of physical countermaneuvers in the management of orthostatic hypotension: efficacy and biofeedback augmentation." 03/01/1985 - "Biofeedback as a treatment for postural hypotension." 02/01/1977 - "A man having severe postural hypotension resulting from a spinal cord lesion at level T3, was trained to raise and lower his blood pressure with the use of biofeedback. " Order ALL the reference details at left...

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