Abstract | BACKGROUND: METHODS: Twenty-three morbidly obese adults underwent anthropometric measurements, polysomnography, and serum biomarker profiling prior to and 1 year following bariatric surgery. We examined the effect of WL and amelioration of sleep apnea on metabolic and inflammatory markers. RESULTS: Surgical WL resulted in significant decreases in BMI (16.7 ± 5.97 kg/m(2)/median 365 days), apnea-hypopnea index (AHI), CRP, IL-6, sTNFαR1, sTNFαR2, and leptin levels, while ghrelin, adiponectin, and soluble leptin receptor concentrations increased significantly. Utilizing an AHI cutoff of 15 events/h, we found significantly elevated levels of baseline sTNFαR2 and greater post-WL sTNFαR2 decreases in subjects with baseline AHI ≥15 events/h compared to those with AHI <15 events/h despite no significant differences in baseline BMI, age, and ΔBMI. In a multivariable linear regression model adjusting for sex, age, impaired glucose metabolism, ΔBMI, and follow-up period, the post-WL decreases in AHI were an independent predictor of the decreases in sTNFαR2 and altogether accounted for 46% of the variance of ΔsTNFαR2 (P = 0.011) in the entire cohort. CONCLUSIONS:
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Authors | Maria Pallayova, Kimberley E Steele, Thomas H Magnuson, Michael A Schweitzer, Philip L Smith, Susheel P Patil, Shannon Bevans-Fonti, Vsevolod Y Polotsky, Alan R Schwartz |
Journal | Obesity surgery
(Obes Surg)
Vol. 21
Issue 9
Pg. 1413-23
(Sep 2011)
ISSN: 1708-0428 [Electronic] United States |
PMID | 21298510
(Publication Type: Clinical Trial, Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't)
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Chemical References |
- Adipokines
- Biomarkers
- Receptors, Tumor Necrosis Factor, Type II
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Topics |
- Adipokines
(blood)
- Adiposity
- Adult
- Bariatric Surgery
- Biomarkers
(blood)
- Body Mass Index
- Female
- Humans
- Linear Models
- Longitudinal Studies
- Male
- Middle Aged
- Multivariate Analysis
- Obesity, Morbid
(blood, complications, physiopathology, surgery)
- Polysomnography
- Receptors, Tumor Necrosis Factor, Type II
(blood)
- Sex Factors
- Sleep Apnea Syndromes
(blood, complications)
- Treatment Outcome
- Weight Loss
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