Abstract |
Polycystic ovary syndrome (PCOS), the commonest endocrine disorder in women, is characterized by an altered steroid milieu and is associated with insulin resistance and type 2 diabetes mellitus (T2DM). Phosphoprotein enriched in diabetes gene product (Ped/pea-15) regulates glucose metabolism and is increased in T2DM. Our novel data indicate that Ped/pea-15 mRNA expression and protein levels are significantly increased in omental adipose tissue (AT) from PCOS women compared to matched controls (p < 0.01); Ped/pea-15 levels in subcutaneous AT were not significantly different. Furthermore, Ped/pea-15 mRNA expression and protein levels were higher in omental compared to subcutaneous AT in PCOS subjects (p < 0.01); however, in control subjects, this was not significant. Glucose was predictive of omental AT Ped/pea-15 mRNA expression (p = 0.045). Importantly, glucose and insulin increased whereas metformin significantly decreased Ped/pea-15 levels in human omental AT explants. Our findings should serve to promote further research on Ped/pea-15 biology.
|
Authors | B K Tan, J Chen, R Adya, H S Randeva |
Journal | Diabetes, obesity & metabolism
(Diabetes Obes Metab)
Vol. 13
Issue 2
Pg. 181-4
(Feb 2011)
ISSN: 1463-1326 [Electronic] England |
PMID | 21199270
(Publication Type: Letter, Research Support, Non-U.S. Gov't)
|
Chemical References |
- Apoptosis Regulatory Proteins
- Biomarkers
- Insulin
- Intracellular Signaling Peptides and Proteins
- PEA15 protein, human
- Phosphoproteins
- Metformin
- Glucose
|
Topics |
- Adipose Tissue
(metabolism)
- Adult
- Apoptosis Regulatory Proteins
- Biomarkers
(metabolism)
- Female
- Glucose
(metabolism)
- Humans
- Insulin
(metabolism)
- Insulin Resistance
(genetics)
- Intracellular Signaling Peptides and Proteins
(genetics)
- Metformin
(metabolism)
- Phosphoproteins
(genetics)
- Polycystic Ovary Syndrome
(drug therapy, genetics, metabolism)
|