[Clinical evaluation and problem of intra-arterial infusion chemotherapy of liver metastasis from digestive organ cancer].

Abstract

Intra-arterial infusion chemotherapy using an implantable reservoir was used for 22 patients with liver metastasis from September 1986 to March 1990. The material consisted of 8 subjects with gastric cancer and 14 with colorectal cancer. One had metastasis in one lobe (H1), 10 had a few scattered metastases in both lobes (H2) and 11 had numerous metastases in both lobes (H3). In 5 cases, a reservoir was implanted to prevent the recurrence after hepatectomy. Infusion catheter was placed in the proper hepatic artery in 5 cases via the gastroduodenal artery at laparotomy and it was carried out subcutaneously via the femoral artery in 17 cases. In all cases intra-arterial infusion of 5-FU was continuously administered followed by intermittent one shot injection of ADM. The clinical effectiveness of the therapy was well evaluated. One-year cumulative survival rate of all cases by Kaplan-Meier method was 55% and that of H2 cases was 78%. No recurrence was noted in post hepatectomy cases. Eight cases (36.3%) showed remarkable complications, which made it impossible to continue intra-arterial infusion chemotherapy: hepatic artery occlusion (3 cases), infection (2 cases), abdominal pain (1 case), hematoma in the implanted site (1 case) and dislocation of the infusion catheter (1 case). From the present study, it is considered that intra-arterial infusion chemotherapy is a useful procedure for the control of liver metastasis. Regimens for improved chemotherapy and the maintenance of more useful and safer catheters should therefore be investigated for further development of the therapeutical estimation.

• Authors: T Ohya, J Fukunaga, H Kitahama, A Okuyama, T Seki, K Tsurui, M Saka, M Sasagawa, S Hishinuma, K Kotake
• Journal: Gan to kagaku ryoho. Cancer & chemotherapy (Gan To Kagaku Ryoho) Vol. 17 Issue 8 Pt 2 Pg. 1808-10 (Aug 1990) ISSN: 0385-0684 [Print] Japan
• PMID: 2117905 (Publication Type: English Abstract, Journal Article)

Chemical References

• Mitomycins
• Mitomycin
• Fluorouracil

Topics

• Colorectal Neoplasms (pathology)
• Drug Administration Schedule
• Fluorouracil (administration & dosage)
• Humans
• Infusion Pumps, Implantable
• Infusions, Intra-Arterial
• Liver Neoplasms (drug therapy, mortality, secondary)
• Mitomycin
• Mitomycins (administration & dosage)
• Prognosis
• Stomach Neoplasms (pathology)
• Survival Rate