Abstract | BACKGROUND & AIMS: Oxidative/nitrosative stress plays an important role in the pathogenesis of hepatic encephalopathy and ammonia toxicity. The present study was undertaken in order to investigate the impact of portal vein ligation on cerebrocortical oxidative stress and its relation to locomotor activity. METHODS: Cerebral protein tyrosine nitration, RNA oxidation, locomotor activity, and microglia activation were studied in rats that underwent portal vein ligation (PVL). RESULTS: CONCLUSIONS: The data suggest that PVL triggers oxidative/nitrosative stress in the brain without activation of microglia and neuroinflammation. Prevention of protein tyrosine nitration and RNA oxidation by indomethacin also prevents the disturbances in locomotor activity pointing to a relevance of oxidative stress in the pathophysiology of HE.
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Authors | Jonathan Brück, Boris Görg, Hans-Jürgen Bidmon, Irinia Zemtsova, Natalia Qvartskhava, Verena Keitel, Gerald Kircheis, Dieter Häussinger |
Journal | Journal of hepatology
(J Hepatol)
Vol. 54
Issue 2
Pg. 251-7
(Feb 2011)
ISSN: 1600-0641 [Electronic] Netherlands |
PMID | 21084134
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Copyright | Copyright © 2010 European Association for the Study of the Liver. Published by Elsevier B.V. All rights reserved. |
Chemical References |
- Cytokines
- RNA, Messenger
- Tyrosine
- Nitric Oxide Synthase Type II
- Indomethacin
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Topics |
- Animals
- Cerebral Cortex
(metabolism)
- Cytokines
(genetics)
- Hepatic Encephalopathy
(etiology)
- Hyperammonemia
(etiology)
- Indomethacin
(pharmacology)
- Ligation
- Male
- Microglia
(physiology)
- Motor Activity
- Nitric Oxide Synthase Type II
(analysis)
- Oxidative Stress
- Portal Vein
(physiology)
- RNA, Messenger
(analysis)
- Rats
- Rats, Wistar
- Tyrosine
(metabolism)
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