Inflammation and genetic risk indicators for early periodontitis in adults.

Abstract

BACKGROUND:

This report is a further analysis of a study designed to determine clinical and microbial risk indicators for progressing periodontitis.

METHODS:

One hundred ninety subjects who were periodontally healthy or had early signs of periodontitis (age range: 20 to 40 years) were monitored clinically at 6-month intervals followed by supragingival cleaning. At each visit, gingival crevicular fluid (GCF) and blood were collected for determination of interleukin (IL)-1β content (in GCF) and IL-1 genotype (in blood). Interproximal sites with a >1.5-mm increase in clinical attachment over 18 months were considered disease active. Characteristics were compared between active and inactive subjects.

RESULTS:

IL-1β levels in GCF increased with the severity of disease and correlated well with clinical signs of incipient disease. However, the IL-1 genotype did not show any significant associations with disease or the extent of disease.

CONCLUSION:

Indicators of inflammation may be important clinical determinants of future periodontal disease progression, but the IL-1 genotype was not a risk indictor for early (slight) periodontitis as defined in this subject population.

• Authors: Philip Stashenko, Thomas Van Dyke, Patrice Tully, Ralph Kent, Stephen Sonis, Anne C R Tanner
• Journal: Journal of periodontology (J Periodontol) Vol. 82 Issue 4 Pg. 588-96 (Apr 2011) ISSN: 1943-3670 [Electronic] United States
• PMID: 21054222 (Publication Type: Journal Article, Multicenter Study, Research Support, N.I.H., Extramural, Research Support, U.S. Gov't, Non-P.H.S.)

Chemical References

• Interleukin-1beta

Topics

• Adult
• Age of Onset
• Female
• Genetic Predisposition to Disease
• Gingival Crevicular Fluid (immunology)
• Humans
• Inflammation (immunology)
• Interleukin-1beta (analysis, genetics)
• Longitudinal Studies
• Male
• Periodontitis (genetics, immunology)
• Severity of Illness Index
• Young Adult