Abstract | BACKGROUND: METHODS: Cases were retrospectively identified through the drug safety unit database of Rennes University Hospital. RESULTS: From 1994 to 2009, interstitial pneumonia developed in 15 patients following (131)I-labeled lipiodol administration, with an estimated prevalence of 15.5 cases (95% CI, 7.7-23.2) per 1,000 treated patients. Mean age of the patients was 60 ± 8 years, and the male to female ratio was 6.5:1. All patients had cirrhosis, mainly related to long-term alcohol intoxication (n = 12). Most (n = 10) cases occurred after the second (131)I-labeled lipiodol injection. The median delay between last (131)I-labeled lipiodol administration and first respiratory symptoms was 30 days (interquartile range, 16.5-45 days). All patients presented with shortness of breath. Physical examination mostly revealed fever (n = 11) and bilateral crackles (n = 12). Chest CT scan showed bilateral ground-glass opacities (n = 8) with septal thickening, retraction, or both (n = 8). BAL (n = 7) was remarkable for increased neutrophils (n = 4) or CD8(+) T cell count (n = 3). Despite corticosteroids, 12 (80%) patients died, mostly of untractable respiratory failure (n = 9). Median delay between last (131)I-labeled lipiodol injection and death was 63 days (interquartile range, 34-129 days). CONCLUSIONS:
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Authors | Stéphane Jouneau, Elodie Vauléon, Sylvie Caulet-Maugendre, Elisabeth Polard, Anne-Claire Volatron, Catherine Meunier, Pierre Tattevin, David Montani, Etienne Garin, Jean-Luc Raoul, Philippe Delaval |
Journal | Chest
(Chest)
Vol. 139
Issue 6
Pg. 1463-1469
(Jun 2011)
ISSN: 1931-3543 [Electronic] United States |
PMID | 20947651
(Publication Type: Journal Article)
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Chemical References |
- Antineoplastic Agents
- Iodine Radioisotopes
- Ethiodized Oil
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Topics |
- Aged
- Antineoplastic Agents
(administration & dosage, adverse effects)
- Carcinoma, Hepatocellular
(drug therapy, mortality, pathology)
- Ethiodized Oil
(administration & dosage, adverse effects)
- Female
- Humans
- Injections, Intra-Arterial
- Iodine Radioisotopes
(administration & dosage, adverse effects)
- Liver Neoplasms
(drug therapy, mortality, pathology)
- Lung Diseases, Interstitial
(chemically induced, diagnosis, mortality)
- Male
- Middle Aged
- Retrospective Studies
- Treatment Outcome
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