Imaging non-motor aspects of Parkinson's disease.

Abstract

In this chapter the imaging changes associated with non-motor aspects of Parkinson's disease (PD) are reviewed. The relationship between reduced monoaminergic and cholinergic function and cognitive difficulties, depression, fatigue, sleep disorders, and dysautonomia is discussed and the relevance of Alzheimer pathology to PD dementia debated. Finally the discordance between the development of functional changes in PD and Braak staging is highlighted.

• Authors: David J Brooks, Nicola Pavese
• Journal: Progress in brain research (Prog Brain Res) Vol. 184 Pg. 205-18 ( 2010) ISSN: 1875-7855 [Electronic] Netherlands
• PMID: 20887877 (Publication Type: Journal Article, Review)
• Copyright: Copyright © 2010 Elsevier B.V. All rights reserved.

Chemical References

• Glucose
• Dopamine

Topics

• Aged
• Animals
• Brain Chemistry (physiology)
• Cognition Disorders (complications)
• Depressive Disorder (etiology, psychology)
• Dopamine (physiology)
• Fatigue (etiology)
• Female
• Glucose (metabolism)
• Humans
• Male
• Middle Aged
• Parasympathetic Nervous System (pathology)
• Parkinson Disease (complications, metabolism, pathology)
• Plaque, Amyloid (complications, pathology)
• Sleep Wake Disorders (etiology, pathology)
• Smell (physiology)
• Sympathectomy