Abstract | PURPOSE: PATIENTS AND METHODS: Two hundred eighty-two adolescents and adults with de novo Philadelphia chromosome (Ph)-negative precursor B-lineage ALL were treated with standard or modified hyper-CVAD regimens. The latter incorporated standard-dose rituximab if CD20 expression > or = 20%. RESULTS: The complete remission (CR) rate was 95% with 3-year rates of CR duration (CRD) and survival (OS) of 60% and 50%, respectively. In the younger (age < 60 years) CD20-positive subset, rates of CRD and OS were superior with the modified hyper-CVAD and rituximab regimens compared with standard hyper-CVAD (70% v 38%; P < .001% and 75% v 47%, P = .003). In contrast, rates of CRD and OS for CD20-negative counterparts treated with modified versus standard hyper-CVAD regimens were similar (72% v 68%, P = not significant [NS] and 64% v 65%, P = NS, respectively). Older patients with CD20-positive ALL did not benefit from rituximab-based chemoimmunotherapy (rates of CRD 45% v 50%, P = NS and OS 28% v 32%, P = NS, respectively), related in part to deaths in CR. CONCLUSION: The incorporation of rituximab into the hyper-CVAD regimen appears to improve outcome for younger patients with CD20-positive Ph-negative precursor B-lineage ALL.
|
Authors | Deborah A Thomas, Susan O'Brien, Stefan Faderl, Guillermo Garcia-Manero, Alessandra Ferrajoli, William Wierda, Farhad Ravandi, Srdan Verstovsek, Jeffrey L Jorgensen, Carlos Bueso-Ramos, Michael Andreeff, Sherry Pierce, Rebecca Garris, Michael J Keating, Jorge Cortes, Hagop M Kantarjian |
Journal | Journal of clinical oncology : official journal of the American Society of Clinical Oncology
(J Clin Oncol)
Vol. 28
Issue 24
Pg. 3880-9
(Aug 20 2010)
ISSN: 1527-7755 [Electronic] United States |
PMID | 20660823
(Publication Type: Clinical Trial, Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't)
|
Chemical References |
- Antibodies, Monoclonal
- Antibodies, Monoclonal, Murine-Derived
- Immunologic Factors
- Rituximab
- Vincristine
- Dexamethasone
- Doxorubicin
- Cyclophosphamide
|
Topics |
- Adolescent
- Adult
- Aged
- Antibodies, Monoclonal
(administration & dosage)
- Antibodies, Monoclonal, Murine-Derived
- Antineoplastic Combined Chemotherapy Protocols
(administration & dosage, therapeutic use)
- Cyclophosphamide
(administration & dosage)
- Dexamethasone
(administration & dosage)
- Doxorubicin
(administration & dosage)
- Female
- Humans
- Immunologic Factors
(administration & dosage)
- Kaplan-Meier Estimate
- Male
- Middle Aged
- Philadelphia Chromosome
- Precursor B-Cell Lymphoblastic Leukemia-Lymphoma
(drug therapy)
- Prognosis
- Remission Induction
- Rituximab
- Treatment Outcome
- Vincristine
(administration & dosage)
- Young Adult
|