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Philadelphia Chromosome

An aberrant form of human CHROMOSOME 22 characterized by translocation of the distal end of chromosome 9 from 9q34, to the long arm of chromosome 22 at 22q11. It is present in the bone marrow cells of 80 to 90 per cent of patients with chronic myelocytic leukemia (LEUKEMIA, MYELOGENOUS, CHRONIC, BCR-ABL POSITIVE).
Also Known As:
Ph 1 Chromosome; 1 Chromosomes, Ph; Chromosome, Ph 1; Chromosome, Ph1; Chromosome, Philadelphia; Chromosomes, Ph 1; Chromosomes, Ph1; Ph 1 Chromosomes; Ph1 Chromosomes; Ph1 Chromosome
Networked: 2658 relevant articles (357 outcomes, 260 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1. Precursor Cell Lymphoblastic Leukemia-Lymphoma (Acute Lymphoblastic Leukemia)
2. BCR-ABL Positive Chronic Myelogenous Leukemia (Chronic Myelogenous Leukemia)
3. Leukemia
4. Neoplasms (Cancer)
5. Chromosome Aberrations (Chromosome Abnormalities)

Experts

1. Kantarjian, Hagop M: 79 articles (09/2022 - 04/2002)
2. Kantarjian, Hagop: 72 articles (01/2022 - 02/2002)
3. Cortes, Jorge: 70 articles (01/2022 - 04/2002)
4. O'Brien, Susan: 63 articles (01/2021 - 04/2002)
5. Garcia-Manero, Guillermo: 60 articles (09/2022 - 04/2002)
6. Jabbour, Elias: 56 articles (05/2022 - 05/2007)
7. Ravandi, Farhad: 51 articles (09/2022 - 09/2006)
8. Cortes, Jorge E: 43 articles (12/2021 - 07/2002)
9. Talpaz, Moshe: 43 articles (12/2019 - 02/2002)
10. Hochhaus, Andreas: 39 articles (01/2022 - 02/2002)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Philadelphia Chromosome:
1. Imatinib Mesylate (Gleevec)FDA Link
2. Tyrosine Kinase InhibitorsIBA
3. Dasatinib (BMS 354825)FDA Link
4. bcr-abl Fusion ProteinsIBA
5. nilotinibFDA Link
6. blinatumomabIBA
7. ponatinibIBA
8. Interferon-alpha (Interferon Alfa)IBA
9. Phosphotransferases (Kinase)IBA
10. InterferonsIBA

Therapies and Procedures

1. Drug Therapy (Chemotherapy)
2. Therapeutics
3. Stem Cell Transplantation
4. Hematopoietic Stem Cell Transplantation
5. Transplantation