Serum-surfactant SP-D correlates inversely to lung function in cystic fibrosis.

Abstract

BACKGROUND:

Cystic fibrosis (CF) affects the lungs causing infections and inflammation. Surfactant protein D (SP-D) is an innate defense lectin primarily secreted in the lungs. We investigated the influence of the SP-D Met11Thr polymorphism on CF lung function; and serum SP-D as a marker for CF lung disease.

METHODS:

For 107 CF patients (73 children, and 34 adults) serum SP-D and SP-D Met11Thr genotype were available. Leukocyte count was obtained for a subset of patients. Lung function was measured as forced expiratory volume in one second (FEV-1).

RESULTS:

Serum SP-D was increased in CF patients compared to healthy controls, positively correlated to leukocyte count, and negatively correlated to FEV-1. We found no correlation between SP-D Met11Thr genotype and FEV-1, and we found corresponding genotype frequencies in CF patients and in healthy controls.

CONCLUSION:

Serum SP-D in CF patients was increased in parallel with leukocyte count and with reduced FEV-1 and may constitute an alternative biomarker for lung disease, in the clinical setting and in research.

• Authors: Hanne Vebert Olesen, Uffe Holmskov, Peter Oluf Schiøtz, Grith Lykke Sørensen
• Journal: Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society (J Cyst Fibros) Vol. 9 Issue 4 Pg. 257-62 (Jul 2010) ISSN: 1873-5010 [Electronic] Netherlands
• PMID: 20457545 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
• Copyright: Copyright 2010 European Cystic Fibrosis Society. Published by Elsevier B.V. All rights reserved.

Chemical References

• Biomarkers
• Pulmonary Surfactant-Associated Protein D

Topics

• Adolescent
• Adult
• Aged
• Biomarkers (blood)
• Case-Control Studies
• Child
• Cystic Fibrosis (blood, physiopathology)
• Female
• Forced Expiratory Volume
• Humans
• Leukocyte Count
• Male
• Middle Aged
• Polymorphism, Single Nucleotide
• Pulmonary Surfactant-Associated Protein D (blood, genetics)
• Young Adult