Effects of combination of sibutramine and L-carnitine compared with sibutramine monotherapy on inflammatory parameters in diabetic patients.

Abstract

The aim of the study was to evaluate the effects of 12-month treatment with sibutramine plus L-carnitine compared with sibutramine alone on body weight, glycemic control, insulin resistance, and inflammatory state in type 2 diabetes mellitus patients. Two hundred fifty-four patients with uncontrolled type 2 diabetes mellitus (glycated hemoglobin [HbA(1c)] >8.0%) in therapy with different oral hypoglycemic agents or insulin were enrolled in this study and randomized to take sibutramine 10 mg plus L-carnitine 2 g or sibutramine 10 mg in monotherapy. We evaluated at baseline and after 3, 6, 9, and 12 months these parameters: body weight, body mass index, HbA(1c), fasting plasma glucose, postprandial plasma glucose, fasting plasma insulin, homeostasis model assessment of insulin resistance index, total cholesterol, low-density lipoprotein cholesterol, high-density lipoprotein cholesterol, triglycerides, leptin, tumor necrosis factor-α, adiponectin, vaspin, and high-sensitivity C-reactive protein. Sibutramine plus L-carnitine gave a faster improvement of fasting plasma glucose, postprandial plasma glucose, lipid profile, leptin, tumor necrosis factor-α, and high-sensitivity C-reactive protein compared with sibutramine alone. Furthermore, there was a better improvement of body weight, HbA(1c), fasting plasma insulin, homeostasis model assessment of insulin resistance index, vaspin, and adiponectin with sibutramine plus L-carnitine compared with sibutramine alone. Sibutramine plus L-carnitine gave a better and faster improvement of all the analyzed parameters compared with sibutramine alone without giving any severe adverse effect.

• Authors: Giuseppe Derosa, Pamela Maffioli, Sibilla A T Salvadeo, Ilaria Ferrari, Alessia Gravina, Roberto Mereu, Angela D'Angelo, Ilaria Palumbo, Sabrina Randazzo, Arrigo F G Cicero
• Journal: Metabolism: clinical and experimental (Metabolism) Vol. 60 Issue 3 Pg. 421-9 (Mar 2011) ISSN: 1532-8600 [Electronic] United States
• PMID: 20423740 (Publication Type: Comparative Study, Journal Article, Multicenter Study, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)
• Copyright: Copyright © 2011 Elsevier Inc. All rights reserved.

Chemical References

• Appetite Depressants
• Blood Glucose
• Cyclobutanes
• Glycated Hemoglobin A
• Leptin
• Tumor Necrosis Factor-alpha
• Vitamin B Complex
• C-Reactive Protein
• Cholesterol
• Carnitine
• sibutramine

Topics

• Aged
• Appetite Depressants (administration & dosage)
• Blood Glucose (metabolism)
• Body Weight (drug effects)
• C-Reactive Protein (metabolism)
• Carnitine (administration & dosage)
• Cholesterol (blood)
• Cyclobutanes (administration & dosage)
• Diabetes Mellitus, Type 2 (blood, drug therapy)
• Double-Blind Method
• Drug Therapy, Combination
• Female
• Glycated Hemoglobin (metabolism)
• Humans
• Insulin Resistance
• Leptin (blood)
• Longitudinal Studies
• Male
• Middle Aged
• Tumor Necrosis Factor-alpha (blood)
• Vitamin B Complex (administration & dosage)