Associations of metabolic parameters and ethanol consumption with messenger RNA expression of clock genes in healthy men.

Abstract	Recent studies suggest that the impairment of circadian clock function causes various pathological conditions, such as obesity, diabetes, and alcoholism, and an altered mRNA expression of clock genes was found under these conditions. However, it remains to be determined whether clock gene expression varies depending on metabolic conditions even in healthy people. To address this issue, we investigated the associations of metabolic parameters and alcohol consumption with mRNA expression of clock genes (CLOCK, BMAL1, PER1, PER2, and PER3) in peripheral blood cells obtained from 29 healthy non-obese elderly men (age 51-78 yrs) who adhered to a regular sleep-wake routine, through a single time-of-day venous blood sampling at approximately 09:00 h. There were significant correlations between (1) waist circumference and mRNA level of PER1 (r =-0.43), (2) plasma glucose concentration and PER2 (r =-0.50), (3) ethanol consumption and BMAL1 (r =-0.43), and (4) serum gamma-GTP concentration (a sensitive marker of alcohol consumption) and PER2 (r =-0.40). These results suggest mRNA expression of clock genes is associated with obesity, glucose tolerance, and ethanol consumption even in healthy people.
Authors	Hitoshi Ando, Kentarou Ushijima, Masafumi Kumazaki, Takashi Eto, Toshinari Takamura, Shin Irie, Shuichi Kaneko, Akio Fujimura
Journal	Chronobiology international (Chronobiol Int) Vol. 27 Issue 1 Pg. 194-203 (Jan 2010) ISSN: 1525-6073 [Electronic] England
PMID	20205566 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References	ARNTL Transcription Factors ARNTL protein, human Blood Glucose Circadian Rhythm Signaling Peptides and Proteins PER1 protein, human PER2 protein, human PER3 protein, human Period Circadian Proteins RNA, Messenger CLOCK Proteins CLOCK protein, human
Topics	ARNTL Transcription Factors (genetics) Aged Alcohol Drinking (genetics, metabolism) Blood Glucose (metabolism) CLOCK Proteins (genetics) Circadian Rhythm (genetics, physiology) Circadian Rhythm Signaling Peptides and Proteins (genetics) Gene Expression Humans Male Middle Aged Period Circadian Proteins (genetics) RNA, Messenger (blood, genetics) Waist Circumference

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.

Realize the full power of the drug-disease research graph!