Abstract | OBJECTIVE: DATA SOURCES: STUDY SELECTION AND DATA EXTRACTION: Phase 2 and 3 clinical trials evaluating immunogenicity and safety of DTaP-IPV and DTaP-IPV/Hib were reviewed. Published trials were supplemented with abstracts, review articles, manufacturer product labeling, and CDC recommendations. DATA SYNTHESIS: DTaP-IPV is immunogenic compared to its component vaccines,with no effect of concomitantly administered measles, mumps, and rubella vaccine.Although injection site pain has occurred more with the combination vaccine, its use would reduce by 1 the number of injections given when a child is 4-6 years old.DTaP-IPV/Hib is immunogenic and safe compared to separate vaccines.Immunogenicity to 7-valent pneumococcal conjugate vaccine and hepatitis B( HepB) vaccine is not affected by concomitant administration. DTaP-IPV/Hib decreases injections by up to 7 when given at 2, 4, 6, and 15-18 months of age. It fits into the schedule more easily than DTaP- HepB-IPV ( Pediarix), the other DTaP containing combination vaccine indicated for the primary infant series. CONCLUSIONS: DTaP-IPV and DTaP-IPV/Hib combination vaccines are immunogenic and safe when given to infants and children. They reduce the number of required injections. Combination vaccines are encouraged to promote timely vaccination and complete immunization schedules.
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Authors | Tracy L Johns, George E Hutter |
Journal | The Annals of pharmacotherapy
(Ann Pharmacother)
Vol. 44
Issue 3
Pg. 515-23
(Mar 2010)
ISSN: 1542-6270 [Electronic] United States |
PMID | 20197476
(Publication Type: Comparative Study, Journal Article, Review)
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Chemical References |
- Diphtheria-Tetanus-acellular Pertussis Vaccines
- Haemophilus Vaccines
- Poliovirus Vaccine, Inactivated
- Vaccines, Combined
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Topics |
- Child
- Child, Preschool
- Diphtheria-Tetanus-acellular Pertussis Vaccines
(administration & dosage, adverse effects, immunology)
- Haemophilus Vaccines
(administration & dosage, adverse effects, immunology)
- Haemophilus influenzae type b
(immunology)
- Humans
- Immunization Schedule
- Immunization, Secondary
- Infant
- Poliovirus Vaccine, Inactivated
(administration & dosage, adverse effects, immunology)
- Vaccines, Combined
(adverse effects, immunology)
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