Abstract | BACKGROUND: METHODS: RESULTS: Patients in the treatment arm received silybin-phytosome for 14-31 days (mean was 20 days) prior to surgery. Silibinin blood levels were measured 1 hr after the first silybin-phytosome dose with a mean value of 19.7 microM. Trough silibinin levels were assessed at the end of the trial with an average concentration of 1.2 microM. In contrast to the high peak levels of silibinin observed in blood, the highest silibinin level observed in the harvested prostate tissue was 496.6 pmol/g. There were no significant differences noted in baseline and post-treatment blood levels of IGF-I and IGFBP-3. One of the treated patients developed a grade 4 post-operative thromboembolic event. The other observed toxicities in the treatment group were mild: four subjects had diarrhea and one had asymptomatic grade 2 hyperbilirubinemia which was transient. CONCLUSIONS: High-dose oral silybin-phytosome achieves high blood concentrations transiently, but low levels of silibinin are seen in prostate tissue. Silibinin's lack of tissue penetration may be explained by its short half-life, the brief duration of therapy in this study or an active process removing silibinin from the prostate.
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Authors | Thomas W Flaig, Michael Glodé, Daniel Gustafson, Adrie van Bokhoven, Yuzhen Tao, Shandra Wilson, Lih-Jen Su, Yuan Li, Gail Harrison, Rajesh Agarwal, E David Crawford, M Scott Lucia, Michael Pollak |
Journal | The Prostate
(Prostate)
Vol. 70
Issue 8
Pg. 848-55
(Jun 01 2010)
ISSN: 1097-0045 [Electronic] United States |
PMID | 20127732
(Publication Type: Clinical Trial, Phase II, Journal Article, Research Support, N.I.H., Extramural)
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Chemical References |
- Antineoplastic Agents, Phytogenic
- Antioxidants
- Insulin-Like Growth Factor Binding Protein 3
- Silymarin
- Silybin
- Insulin-Like Growth Factor I
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Topics |
- Aged
- Antineoplastic Agents, Phytogenic
(pharmacokinetics, therapeutic use)
- Antioxidants
(pharmacokinetics, therapeutic use)
- Combined Modality Therapy
- Humans
- Insulin-Like Growth Factor Binding Protein 3
(blood)
- Insulin-Like Growth Factor I
(metabolism)
- Male
- Middle Aged
- Prostate
(surgery)
- Prostatectomy
- Prostatic Neoplasms
(drug therapy, surgery)
- Silybin
- Silymarin
(pharmacokinetics, therapeutic use)
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