Hyperbilirubinemia

A condition characterized by an abnormal increase of BILIRUBIN in the blood, which may result in JAUNDICE. Bilirubin, a breakdown product of HEME, is normally excreted in the BILE or further catabolized before excretion in the urine.

Also Known As:

Networked: 4467 relevant articles (182 outcomes, 420 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1.	Cholestasis
2.	Liver Failure
3.	Kernicterus
4.	Jaundice (Icterus)
5.	Brain Diseases (Brain Disorder)

Experts

1.	Stevenson, David K: 24 articles (01/2021 - 10/2002)
2.	Wong, Ronald J: 22 articles (01/2021 - 10/2004)
3.	Bhutani, Vinod K: 21 articles (12/2022 - 08/2004)
4.	Kaplan, Michael: 20 articles (01/2021 - 10/2002)
5.	Hammerman, Cathy: 19 articles (11/2019 - 10/2002)
6.	Newman, Thomas B: 18 articles (01/2021 - 05/2003)
7.	Vreman, Hendrik J: 15 articles (01/2020 - 10/2002)
8.	Verkade, Henkjan J: 14 articles (01/2021 - 03/2005)
9.	Tiribelli, Claudio: 12 articles (06/2022 - 04/2006)
10.	Watchko, Jon F: 12 articles (01/2022 - 10/2006)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Hyperbilirubinemia:

1.	BilirubinIBA 01/01/2021 - "Great progress has been achieved over the last 100 years in the development of noninvasive methods for diagnosing indirect hyperbilirubinemia in the neonate, from simple visual assessment to the most advanced noninvasive devices that provide accurate measurements when compared to the gold standard blood test (ie, serum bilirubin)." 01/01/2019 - "Existing guidelines can be further improved to optimize timing of bilirubin measurements to avoid toxic hyperbilirubinemia in high-risk patients while minimizing unneeded measurements in neonates who are at low risk." 01/01/2017 - "Area under the receiver operating characteristic curve for unbound bilirubin (0.78) was significantly greater (p=0.03) than TSB (0.54) among neonates with severe but not extreme hyperbilirubinemia. " 12/01/2010 - "The Bhutani et al bilirubin nomogram reliably identified infants at gestational age of older than 35 weeks with direct Coombs-positive results who were at risk for significant hyperbilirubinemia and directed the timing of follow-up for these infants. " 01/01/1999 - "A single dose of SnMP proved effective in controlling severe hyperbilirubinemia in full-term breastfed newborns with high bilirubin levels between 48 and 96 hours. "
2.	EnzymesIBA 12/01/1992 - "The characteristics of her transient hepatic dysfunction were: early appearance (during the first day of life); discrepancy between the normal liver enzymes and high GGT concentrations; slow decrease of GGT, which nevertheless remained at above-normal concentrations even after the complete disappearance of direct hyperbilirubinemia; and spontaneous resolution in spite of only occasional breastfeeding. " 04/01/2017 - "The conjugated hyperbilirubinemia, liver enzymes and International Normalised Ratio (INR) were gradually improved with normalization by eight weeks. " 03/01/2020 - "More and more studies have revealed the association between the variation of the encoding genes for these enzymes and hyperbilirubinemia. " 01/01/2017 - "This study aimed to characterise the role of UGT1A1 inhibition in hyperbilirubinemia and assess the broader potential of these drugs to perpetrate drug-drug interactions arising from UGT enzyme inhibition. " 11/13/2010 - "Although sporadic hepatic enzyme abnormalities were reported in 34 phase 1/2a studies of up to 28-day duration, they demonstrated no dose relationship or association with hyperbilirubinemia. "
3.	SteroidsIBA 03/14/2019 - "MATERIAL AND METHODS Patients with postoperative hyperbilirubinemia (those with conditions such as biliary complications and rejections were excluded) were randomly assigned, in a 2: 1 ratio, to the steroid and control groups. " 05/18/1972 - "IV. Possibility of early prognosis of hyperbilirubinemia in newborn infants using urinary sex steroids]." 03/14/2019 - "CONCLUSIONS Low-dose steroid therapy was effective and safe for treating hyperbilirubinemia caused by early graft dysfunction, and it improved liver function." 03/14/2019 - "Efficacy and Safety of Steroid Therapy for Posttransplant Hyperbilirubinemia Caused by Early Allograft Dysfunction: A Randomized Controlled Trial." 11/01/2016 - " effectiveness of systemic steroid therapy for hyperbilirubinemia is demonstrated by these cases."
4.	AlbuminsIBA 09/01/2015 - "To evaluate the efficacy of pre-exchange transfusion albumin priming in neonates with non-hemolytic hyperbilirubinemia. " 01/01/1963 - "[Experimental animal and clinical studies on the effects of intravenous albumin administration in hyperbilirubinemia]." 04/01/2023 - "Cord blood albumin of ≥3.75 g/dl was seen in 93 neonates, of which 18 (19.4%) developed hyperbilirubinemia after 72 hours of life and 15 (50%) with <3.75 g/dl developed hyperbilirubinemia after 72 hours of life. " 09/01/2015 - "Pre exchange Albumin Administration in Neonates with Hyperbilirubinemia: A Randomized Controlled Trial." 11/01/2013 - "Albumin treatment is neuroprotective in acute hyperbilirubinemia in Gunn rat pups. "
5.	Transaminases (Aminotransferases)IBA 12/01/1990 - "Consequently, no hyperbilirubinemia and abnormal values of the serum transaminases were revealed in these neonates, and good results of nutritional supports were obtained by cyclic TPN. " 02/01/2013 - "Indirect hyperbilirubinemia and associated signs were the most commonly reported AEs in both study treatment groups and were not associated with significant transaminase increases. " 01/01/2003 - "In HG virus monoinfection, biochemical studies revealed the enhanced activity of transaminases and hyperbilirubinemia that was absent in the mixed variant of HGV + HCV. " 11/23/2023 - "All dogs had increased serum transaminase activities, whereas 21/29 and 12/24 had hyperbilirubinemia and neutrophilia, respectively. " 06/21/2023 - "Initial laboratory tests showed hyperbilirubinemia and elevated liver transaminases. "
6.	Hemoglobins (Hemoglobin)IBA 01/01/2022 - "However, Mst1/2&Hmgb1ΔHep mice were smaller, developed hyperbilirubinemia, had more liver injury with intrahepatic biliary defects, and had reduced hemoglobin compared to Mst1/2ΔHep mice. " 05/26/2020 - "Given that their unconjugated hyperbilirubinemia compared inappropriately with hemolytic severity, as indicated by the hemoglobin level, further combined genetic tests for both UGT1A1 and hereditary erythrocyte deficiencies were conducted. " 01/01/2019 - "We present the case of a 2-month-old infant presenting with pallor and laboratory results showing: hemoglobin 5.1 (10 to 1.5) g/dL, MCV 94.7 (75 to 105) fL, leukocytes 17.4 (7 to 15) ×10/μL, platelets 259 (150 to 450) ×10/μL, hyperbilirubinemia and renal dysfunction. " 01/01/2017 - "One baby (group A, D+) displayed bilirubinemia at birth with a normal hemoglobin level. " 01/01/2016 - "The hemoglobin of the infant decreased from 8.7 to 3.1 g/dl within 48 h, with concomitant severe hyperbilirubinemia (472 μmol/l) requiring exchange transfusion. "
7.	Ursodeoxycholic Acid (Urso)FDA LinkGeneric 07/01/1991 - "Ursodeoxycholic acid (600 mg/day) led to a prompt and sustained improvement in his hyperbilirubinemia. " 09/01/2023 - "The aim of this study was to evaluate the efficiency of ursodeoxycholic acid (UDCA) treatment in newborn infants with prolonged unconjugated hyperbilirubinemia. " 12/01/2023 - "Ursodeoxycholic acid treatment was added to 25 patients with hypertransaminasemia and/or hyperbilirubinemia. " 09/01/2023 - "An evaluation of ursodeoxycholic acid treatment in prolonged unconjugated hyperbilirubinemia due to breast milk." 01/01/2023 - "This study was aimed at evaluating the effect of ursodeoxycholic acid (UDCA) and multistrain synbiotic on indirect hyperbilirubinemia among neonates treated with phototherapy. "
8.	Glucose (Dextrose)FDA LinkGeneric 05/01/1982 - "Refeeding the base-line diet reduced the hyperbilirubinemia by 66% in 12 hours, which was a significantly greater reduction than the effect of all other treatments except the largest dose of glucose given by intragastric route. " 05/01/2009 - "Late preterm infants: severe hyperbilirubinemia and postnatal glucose homeostasis." 07/14/1995 - "Hyperbilirubinemia induced widespread decreases in LCMRglcs at P10 and had rather limited consequences on cerebral glucose utilization at P21. " 03/01/1993 - "Hyperbilirubinemia occurred in 55% of babies in the glucose group compared with 21% and 22% in the saline and control groups, respectively (P < 0.001). " 05/01/1982 - "Effect of glucose administration on equine fasting hyperbilirubinemia."
9.	ClofibrateFDA Link 11/01/1985 - "This study, added to the previous therapeutic trial performed in at term neonates, shows the efficacy of clofibrate in the preventive treatment of hyperbilirubinemia in preterm neonates. " 01/01/2012 - "A systematic review with meta-analysis of randomized controlled trials or quasi-randomized controlled trials was conducted to evaluate the clofibrate treatment in neonates with unconjugated hyperbilirubinemia. " 11/01/1985 - "A double blind therapeutic trial of ethyl clofibrate as a preventive treatment of hyperbilirubinemia in preterm neonates was performed in neonates of gestational ages ranging between 31 and 36 weeks. " 12/01/1981 - "[Clofibrate for the treatment of hyperbilirubinemia in neonates born at term: a double blind controlled study (author's transl)]." 02/01/2012 - "To evaluate the effect of single oral dose of 50 mg/kg clofibrate in hyperbilirubinemia of term healthy neonates in Yazd, Iran. "
10.	Biomarkers (Surrogate Marker)IBA 10/01/2023 - "BAMRs should not be used as a surrogate marker of unbound bilirubinemia, especially in EPT infants at a later postnatal period." 01/01/2019 - " This meta-analysis suggests that the UGT1A1*28 allele represents a biomarker for an increased risk of hyperbilirubinemia in HIV-positive patients receiving ATV." 01/01/2018 - "No validated biomarker at birth exists to predict which newborns will develop severe hyperbilirubinemia. " 07/01/2017 - "We aimed to define if there is any relationship between second trimester serum markers and neonatal severe hyperbilirubinemia to protect the neonates from its neurological damage. " 05/01/2014 - "Hyperbilirubinemia in neonates of diabetic mothers: an indirect biomarker of organ damage?"

Therapies and Procedures

1.	Phototherapy (Light Therapy) 01/01/2023 - "Based on clinical results from a randomised controlled trial showing that home phototherapy for hyperbilirubinemia in term neonates is as effective as hospital phototherapy, we performed a cost-minimisation analysis to identify the most cost-effective alternative. " 07/10/2014 - "This study set out to ascertain maternal experience and satisfaction with a novel treatment of infants with significant hyperbilirubinemia using filtered sunlight phototherapy (FSPT) in a tropical setting with irregular access to effective conventional phototherapy. " 01/01/2000 - "The efficacy of double phototherapy, in the form of conventional phototherapy with special blue light plus fiberoptic phototherapy, was compared with conventional phototherapy consisting of special blue lamps alone in a relatively larger series of term newborns with significant hyperbilirubinemia. " 02/01/1992 - "The latencies of peak V and interpeaks I-V and III-V in the brain-stem auditory evoked response of infants with hyperbilirubinemia before phototherapy were significantly greater than those in a control group of infants. " 02/01/1991 - "These findings suggest that high-dose IVGG may be useful in the treatment of hyperbilirubinemia due to isoimmune haemolytic disease resistant to phototherapy."
2.	Therapeutics 05/01/2006 - "It is effective in treating the hyperbilirubinemia that develops during UFT therapy." 08/11/2015 - "There was improvement in hyperbilirubinemia and a full course of antituberculous therapy without further worsening of the disorder was possible. " 01/01/2022 - "This study aimed to evaluate whether our screening method for hyperbilirubinemia decreased the requirement of blood exchange therapy (ET). " 06/01/2016 - "Exchange transfusion, used as therapy for severe hyperbilirubinemia, trended downwards over the period of this study. " 09/01/1996 - "The aim of this study was to test a possible form of therapy that could be used in the management of unconjugated hyperbilirubinemia. "
3.	Plasma Exchange 01/01/1991 - "This study was undertaken to assort the group of posthepatectomy hyperbilirubinemia by occurring time for helping elucidate its indication of plasma exchange (PE). " 02/01/2018 - "Plasma exchange was intentionally introduced to prevent toxic insult by hyperbilirubinemia immediately after transplant. " 03/01/2015 - "Plasma exchange as a treatment for hyperbilirubinemia in 2 foals with neonatal isoerythrolysis." 06/01/2013 - "Treatment with plasma exchange may serve benefical effect in patients with severe hyperbilirubinemia: a single center experience." 03/01/2002 - "The beneficial effects of plasma exchange could be attributed to amelioration of the toxic effects of hyperbilirubinemia on hepatocyte and renal tubular cell function. "
4.	Liver Transplantation 11/01/2007 - "The aim of this study was to clarify the risk factors for early graft loss and to assess the significance of postoperative hyperbilirubinemia as a predictor of graft outcome in living donor liver transplantation (LDLT). " 12/01/1990 - "During clinical follow-up the recurrence or persistence of hyperbilirubinemia along with deteriorating results of coagulation studies indicated the need for liver transplantation because of imminent poor outcome. " 03/14/2019 - "BACKGROUND Hyperbilirubinemia is a common event that occurs after liver transplantation. " 11/08/2018 - "However, hyperbilirubinemia-induced tooth impairments remain after liver transplantation. " 10/01/2018 - "A new discovery of pathologic hyperbilirubinemia and progression to liver transplant or death during the initial presentation was extremely rare."
5.	Transplantation 01/01/1992 - "In previous studies we demonstrated that transplantation of microencapsulated hepatocytes could correct congenital hyperbilirubinemia in Gunn rats for 4 to 6 wks. " 07/14/2015 - "Amelioration of Hyperbilirubinemia in Gunn Rats after Transplantation of Human Induced Pluripotent Stem Cell-Derived Hepatocytes." 06/01/2015 - "Human neonatal hepatocyte transplantation induces long-term rescue of unconjugated hyperbilirubinemia in the Gunn rat." 09/01/2013 - "CPFA deserves attention as a potential inexpensive short-lasting device to treat hyperbilirubinemia after liver surgery or transplantation. " 06/01/2010 - "The recovery from hyperbilirubinemia and coagulopathy after transplantation was significantly better in patients with a portal pressure <15 mm Hg. In conclusion, our strategy for A-LDLT has changed from larger graft-based A-LDLT to controlled portal pressure-based A-LDLT with smaller grafts. "