Prognostic analysis of the patients with stage-III esophageal squamous cell carcinoma after radical esophagectomy.

Abstract

BACKGROUND AND OBJECTIVE:

Most patients with esophageal carcinoma have disease in the locally late stage (stage III) when first diagnosed, with surgery as the first treatment of choice. This study analyzed the clinical data of patients with esophageal squamous carcinoma after radical esophagectomy and investigated prognostic factors.

METHODS:

The data of 361 patients with esophageal squamous carcinoma who underwent radical esophagectomy and were hospitalized at Sun Yat-sen University Cancer Center between January 1997 and March 2004 were analyzed. The Kaplan-Meier method was used to analyze prognosis, log-rank test was used to compare the groups, and the Cox proportional hazards model was used for multivariate analysis.

RESULTS:

The 1-, 2-, 3-, 4-, and 5-year survival rates were 67.7%, 40.6%, 27.5%, 23.4%, and 20.1%, respectively. Based on univariate analysis, the degree of invasion, rate of lymph node metastasis, number of metastatic regions, number of metastatic lymph nodes, postoperative complications, and duration of surgery were prognostic factors. Based on multivariate analysis, the degree of invasion, rate of lymph node metastasis, and postoperative complications were independent factors for the prognosis.

CONCLUSIONS:

Of all clinical and pathologic factors, the degree of invasion, rate of lymph node metastasis, and postoperative complications were independent prognostic factors for the patients with stage-III esophageal squamous carcinoma after radical esophagectomy.

• Authors: Yi Hu, Bin Zheng, Tie-Hua Rong, Jian-Hua Fu, Zhi-Hua Zhu, Hong Yang, Kong-Jia Luo, Yong-Feng Li
• Journal: Chinese journal of cancer (Chin J Cancer) Vol. 29 Issue 2 Pg. 178-83 (Feb 2010) ISSN: 1000-467X [Print] England
• PMID: 20109347 (Publication Type: Journal Article)

Topics

• Adult
• Aged
• Aged, 80 and over
• Carcinoma, Squamous Cell (pathology, surgery)
• Esophageal Neoplasms (pathology, surgery)
• Esophagectomy (methods)
• Female
• Follow-Up Studies
• Humans
• Lymphatic Metastasis
• Male
• Middle Aged
• Neoplasm Invasiveness
• Neoplasm Staging
• Postoperative Complications
• Proportional Hazards Models
• Retrospective Studies
• Survival Rate