Insulin resistance and overweight-obese women with polycystic ovary syndrome.

Abstract

AIM:

To estimate (1) the prevalence of insulin resistance (IR) by fasting glucose: insulin ratio (G:I) (G:I <or= 4.5) in overweight-obese polycystic ovary syndrome (PCOS) women, (2) to compare the clinical and biochemical parameters between insulin-resistant and insulin-sensitive groups.

MATERIALS AND METHODS:

Eighty-one overweight-obese PCOS women (body mass index (BMI) >or= 23 kg/m(2)) were studied. PCOS was diagnosed as per the Rotterdam 2003 criteria. BMI, abdominal circumference (AC), hirsutism (Ferriman Gallway score >or=6), presence of acne and acanthosis nigricans (AN) were noted in each case. Serum testosterone, sex hormone binding globulin (SHBG), fasting plasma glucose and insulin levels were measured.

RESULTS:

23.5% women were found to have IR. There were no differences in age, frequency of hirsutism, acne, serum testosterone and fasting glucose levels between insulin-resistant and insulin-sensitive women. However, there were significant differences in BMI, AC, frequency of AN, SHBG levels, fasting insulin levels and FAI between the two groups.

CONCLUSION:

PCOS women with IR are more obese; they have more upper body adiposity and AN. They are more hyperandrogenic. Simple clinical parameters will help to suspect IR in PCOS women.

• Authors: Sudhindra Mohan Bhattacharya
• Journal: Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology (Gynecol Endocrinol) Vol. 26 Issue 5 Pg. 344-7 (May 2010) ISSN: 1473-0766 [Electronic] England
• PMID: 19903118 (Publication Type: Journal Article)

Chemical References

• Blood Glucose
• Insulin
• Sex Hormone-Binding Globulin
• Testosterone

Topics

• Acanthosis Nigricans (epidemiology)
• Adolescent
• Adult
• Blood Glucose (analysis)
• Body Mass Index
• Fasting
• Female
• Humans
• Insulin (blood)
• Insulin Resistance
• Obesity (complications)
• Overweight (complications)
• Polycystic Ovary Syndrome (blood, complications, diagnosis)
• Sex Hormone-Binding Globulin (analysis)
• Testosterone (blood)
• Waist Circumference