Abstract | PURPOSE: EXPERIMENTAL DESIGN: The in vivo efficacy and mechanisms of action of oral administration of a standardized extract of W. chinensis were analyzed in animals bearing a subcutaneous or orthotopic prostate cancer xenograft. RESULTS: Exposure of prostate cancer cells to W. chinensis extract induced apoptosis selectively in androgen receptor (AR)-positive prostate cancer cells and shifted the proportion in each phase of cell cycle toward G(2)-M phase in AR-negative prostate cancer cells. Oral herbal extract (4 or 40 mg/kg/d for 24-28 days) attenuated the growth of prostate tumors in nude mice implanted at both subcutaneous (31% and 44%, respectively) and orthotopic (49% and 49%, respectively) sites. The tumor suppression effects were associated with increased apoptosis and lower proliferation in tumor cells as well as reduced tumor angiogenesis. The antitumor effect of W. chinensis extract was correlated with accumulation of the principle active compounds wedelolactone, luteolin, and apigenin in vivo. CONCLUSION:
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Authors | Chin-Hsien Tsai, Feng-Min Lin, Yu-Chih Yang, Ming-Ting Lee, Tai-Lung Cha, Guan-James Wu, Shih-Chuan Hsieh, Pei-Wen Hsiao |
Journal | Clinical cancer research : an official journal of the American Association for Cancer Research
(Clin Cancer Res)
Vol. 15
Issue 17
Pg. 5435-44
(Sep 01 2009)
ISSN: 1557-3265 [Electronic] United States |
PMID | 19690196
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Androgen Antagonists
- Androgen Receptor Antagonists
- Coumarins
- Drugs, Chinese Herbal
- Receptors, Androgen
- wedelolactone
- Apigenin
- Luteolin
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Topics |
- Administration, Oral
- Androgen Antagonists
(pharmacology, therapeutic use)
- Androgen Receptor Antagonists
- Animals
- Apigenin
(pharmacology, therapeutic use)
- Apoptosis
(drug effects, physiology)
- Cell Cycle
(drug effects, physiology)
- Cell Line, Tumor
- Cell Proliferation
(drug effects)
- Coumarins
(pharmacology, therapeutic use)
- Drugs, Chinese Herbal
(pharmacology, therapeutic use)
- Humans
- Luteolin
(pharmacology, therapeutic use)
- Male
- Mice
- Mice, Nude
- Neovascularization, Pathologic
(drug therapy)
- Phytotherapy
- Prostatic Neoplasms
(drug therapy, pathology)
- Receptors, Androgen
(metabolism)
- Wedelia
(chemistry)
- Xenograft Model Antitumor Assays
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