Abstract | BACKGROUND: METHODS: RESULTS: The exercise intolerance was remarkably improved so that she became capable of running. Echocardiography indicated improvements both in the left ventricle ejection fraction and in the fractional shortening. Electrocardiography demonstrated amelioration of the inverted T waves. When the pyruvate administration was interrupted because of a gastrointestinal infection, the serum lactate level became elevated and the serum pyruvate level, decreased, suggesting that the pyruvate administration was effective in decreasing the lactate-to- pyruvate ratio. CONCLUSIONS: GENERAL SIGNIFICANCE:
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Authors | Hirofumi Komaki, Yutaka Nishigaki, Noriyuki Fuku, Hiroko Hosoya, Kei Murayama, Akira Ohtake, Yu-Ichi Goto, Hiroyuki Wakamoto, Yasutoshi Koga, Masashi Tanaka |
Journal | Biochimica et biophysica acta
(Biochim Biophys Acta)
Vol. 1800
Issue 3
Pg. 313-5
(Mar 2010)
ISSN: 0006-3002 [Print] Netherlands |
PMID | 19616603
(Publication Type: Case Reports, Journal Article, Research Support, Non-U.S. Gov't)
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Copyright | Copyright (c) 2009 Elsevier B.V. All rights reserved. |
Chemical References |
- DNA, Mitochondrial
- Pyruvates
- DNA
- Electron Transport Complex IV
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Topics |
- Adult
- Cytochrome-c Oxidase Deficiency
(genetics)
- DNA
(genetics)
- DNA, Mitochondrial
(genetics)
- Electron Transport Complex IV
(genetics)
- Female
- Humans
- Leigh Disease
(drug therapy, enzymology, genetics, pathology)
- Magnetic Resonance Imaging
- Mutation
- Nystagmus, Pathologic
(genetics, pathology)
- Pyruvates
(therapeutic use)
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