Abstract | OBJECTIVE: Chronic rhinosinusitis (CRS) is characterized by persistent inflammation and tissue remodeling of the nasal mucosa. Adenoidectomy is an effective surgical treatment in pediatric CRS. To evaluate the effect of pediatric CRS on the severity and characteristics of adenoid inflammation, the authors evaluated the expressions of inflammatory cell activation markers and tissue remodeling in adenoid tissues associated with cytokines tissue-remodeling-associated cytokines in adenoid tissues. STUDY DESIGN AND SETTING: A prospective controlled study on 40 pediatric patients admitting for adenotonsillectomy. SUBJECTS AND METHODS: RESULTS: The mean levels (the ratio to albumin level) of sIL-2R, TGF-beta1, MMP-2, MMP-9, and TIMP-1 were significantly higher in adenoid tissues of patients with CRS (27.31+/-30.32, 4894.65+/-2388.77, 500.13+/-604.59, and 23.06+/-10.37, respectively) than those without it (16.27+/-10.93, 2635.51+/-1448.63, 120.87+/-321.50, 16.74+/-11.10, and 7.39+/-3.12, respectively; all P<0.05). Regarding the severity of CRS, ECP level was significantly higher in patients with severe CRS than in those with mild to moderate CRS (P=0.033). CONCLUSIONS: Adenoid tissues in pediatric CRS patients had higher levels of tissue-remodeling-associated cytokines, which may explain the relationship between pediatric CRS and adenoid inflammation.
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Authors | Seung-Youp Shin, Gil-Soon Choi, Hae-Sim Park, Kun-Hee Lee, Sung-Wan Kim, Joong-Saeng Cho |
Journal | Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery
(Otolaryngol Head Neck Surg)
Vol. 141
Issue 1
Pg. 91-6
(Jul 2009)
ISSN: 0194-5998 [Print] England |
PMID | 19559965
(Publication Type: Controlled Clinical Trial, Journal Article)
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Chemical References |
- Biomarkers
- Interleukin-6
- Receptors, IgE
- Receptors, Interleukin-2
- Tissue Inhibitor of Metalloproteinase-1
- Transforming Growth Factor beta1
- Eosinophil Cationic Protein
- Tryptases
- Matrix Metalloproteinase 2
- Matrix Metalloproteinase 9
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Topics |
- Adenoids
(immunology)
- Adolescent
- Biomarkers
(analysis)
- Child
- Child, Preschool
- Chronic Disease
- Eosinophil Cationic Protein
(immunology)
- Female
- Humans
- Interleukin-6
(immunology)
- Male
- Matrix Metalloproteinase 2
(immunology)
- Matrix Metalloproteinase 9
(immunology)
- Prospective Studies
- Receptors, IgE
(immunology)
- Receptors, Interleukin-2
(immunology)
- Rhinitis
(immunology)
- Sinusitis
(immunology)
- Statistics, Nonparametric
- Tissue Inhibitor of Metalloproteinase-1
(immunology)
- Transforming Growth Factor beta1
(immunology)
- Tryptases
(immunology)
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