Abstract | AIMS: Non-steroidal anti-inflammatory drugs have been associated with increased risk of congestive heart failure (CHF). We aimed to assess the impact of treatment with etoricoxib or diclofenac on risk of CHF relative to baseline risk factors. METHODS AND RESULTS: We performed a multivariate analysis of 34 701 patients with arthritis receiving etoricoxib 60 or 90 mg, or diclofenac 150 mg, daily for a mean of 18 months, to assess the incidence of confirmed, adjudicated CHF events resulting in emergency room visit or hospitalization. Analyses were performed using a Cox proportional hazard model to evaluate the hazard ratio (HR) between the levels of each risk marker for the incidence of CHF. Significant risk markers included history of CHF (HR: 6.69, 95% CI 3.59-12.47; P <0.0001), age > or = 65 years (2.56, 1.65-3.98; P <0.0001), and history of hypertension (1.83, 1.16-2.89; P = 0.0094) or diabetes (1.83, 1.15-2.94; P = 0.0116). Etoricoxib vs. diclofenac was a significant risk factor only when pooling the etoricoxib 90 mg cohorts (1.88; 1.13-3.10; P = 0.0143). Etoricoxib 60 mg did not significantly increase risk vs. diclofenac. CONCLUSION:
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Authors | Henry Krum, Sean P Curtis, Amarjot Kaur, Hongwei Wang, Steven S Smugar, Matthew R Weir, Loren Laine, D Craig Brater, Christopher P Cannon |
Journal | European journal of heart failure
(Eur J Heart Fail)
Vol. 11
Issue 6
Pg. 542-50
(Jun 2009)
ISSN: 1388-9842 [Print] England |
PMID | 19380329
(Publication Type: Comparative Study, Journal Article, Multicenter Study, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)
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Chemical References |
- Cyclooxygenase Inhibitors
- Pyridines
- Sulfones
- Diclofenac
- Etoricoxib
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Topics |
- Aged
- Arthritis
(drug therapy)
- Cyclooxygenase Inhibitors
(administration & dosage, adverse effects)
- Diclofenac
(administration & dosage, adverse effects)
- Dose-Response Relationship, Drug
- Etoricoxib
- Female
- Follow-Up Studies
- Heart Failure
(chemically induced, epidemiology, physiopathology)
- Humans
- Incidence
- Male
- Middle Aged
- Multivariate Analysis
- Prognosis
- Proportional Hazards Models
- Pyridines
(administration & dosage, adverse effects)
- Retrospective Studies
- Risk Factors
- Sulfones
(administration & dosage, adverse effects)
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