Abstract | BACKGROUND: METHODS: Thirty-one patients with high-risk prostate cancer were treated with docetaxel and gefitinib for 2 months before RP. All patients met the criteria of clinical stage T2b-3 or serum prostate-specific antigen (PSA) level >20 ng/mL, or Gleason score of 8 to 10. The primary endpoint was pathologic complete response. Secondary objectives included clinical response. When available, endorectal coil magnetic resonance imaging (eMRI) was performed as part of clinical response evaluation. Immunohistochemical staining of epidermal growth factor receptor and HER-2/neu was performed on prechemotherapy and postchemotherapy prostate tissue. RESULTS: The median age of the patients was 60 years, the median pretreatment PSA level was 7.43 ng/mL, and the median Gleason score was 8. Clinical staging prior to treatment consisted of: T1 in 4 patients, T2 in 17 patients, and T3 in 10 patients. One patient with enlarged pelvic adenopathy and T4 disease did not undergo RP. Thirty patients received all scheduled therapies including RP. Grade 3 toxicities included asymptomatic liver function test elevation in 4 (13%) patients, diarrhea in 1 (3%) patient, and fatigue in 1 (3%) patient. One patient experienced grade 4 toxicity with elevated alanine aminotransferase. RP specimen pathology demonstrated residual carcinoma in all cases. Twenty-nine (94%) patients achieved a clinical partial response, including 35% of patients who demonstrated radiographic improvement on eMRI. CONCLUSIONS:
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Authors | Jacqueline Vuky, Christopher Porter, Christina Isacson, Matthew Vaughan, Paul Kozlowski, Vincent Picozzi, John Corman |
Journal | Cancer
(Cancer)
Vol. 115
Issue 4
Pg. 784-91
(Feb 15 2009)
ISSN: 0008-543X [Print] United States |
PMID | 19130458
(Publication Type: Clinical Trial, Phase II, Journal Article, Research Support, Non-U.S. Gov't)
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Copyright | (c) 2009 American Cancer Society. |
Chemical References |
- Biomarkers, Tumor
- Quinazolines
- Taxoids
- Docetaxel
- Gefitinib
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Topics |
- Aged
- Antineoplastic Combined Chemotherapy Protocols
(therapeutic use)
- Biomarkers, Tumor
(metabolism)
- Chemotherapy, Adjuvant
- Combined Modality Therapy
- Docetaxel
- Follow-Up Studies
- Gefitinib
- Humans
- Immunoenzyme Techniques
- Male
- Maximum Tolerated Dose
- Middle Aged
- Neoadjuvant Therapy
- Neoplasm Staging
- Prostatectomy
- Prostatic Neoplasms
(drug therapy, secondary, surgery)
- Quinazolines
(administration & dosage)
- Risk Factors
- Taxoids
(administration & dosage)
- Treatment Outcome
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