Abstract | INTRODUCTION: Inflammatory stimuli are causative for insulin resistance in obesity as well as in acute inflammatory reactions. Ongoing research has identified a variety of secreted proteins that are released from immune cells and adipocytes as mediators of insulin resistance; however, knowledge about their relevance for acute inflammatory insulin resistance remains limited. In this study we aimed for a clarification of the relevance of different insulin resistance mediating factors in an acute inflammatory situation. METHODS: RESULTS:
Insulin resistance increased during the observation period and peaked 22 h after the beginning of the operation. IL6 and TNFalpha displayed an early increase with peak concentrations at the 4-h time point. Serum levels of cortisol, resistin and leptin increased more slowly and peaked at the 22-h time point, while adiponectin declined, reaching a base at the 22-h time point. Model assessment identified cortisol as the best predictor of insulin resistance, followed by IL6, leptin and adiponectin. No additional information was gained by modelling for TNFalpha, resistin, catecholamine infusion rate, sex, age, body mass index (BMI), operation time or medication. CONCLUSIONS:
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Authors | Michael Lehrke, Uli C Broedl, Ingeborg M Biller-Friedmann, Michael Vogeser, Volkmar Henschel, Kirsten Nassau, Burkhard Göke, Erich Kilger, Klaus G Parhofer |
Journal | Critical care (London, England)
(Crit Care)
Vol. 12
Issue 6
Pg. R157
( 2008)
ISSN: 1466-609X [Electronic] England |
PMID | 19087258
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Adiponectin
- Biomarkers
- Interleukin-6
- Leptin
- Hydrocortisone
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Topics |
- Adiponectin
(blood)
- Aged
- Biomarkers
(blood)
- Cardiac Surgical Procedures
- Female
- Germany
- Glycemic Index
- Humans
- Hydrocortisone
(blood)
- Inflammation
(diagnosis)
- Insulin Resistance
(physiology)
- Interleukin-6
(blood)
- Leptin
(blood)
- Male
- Middle Aged
- Prospective Studies
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