[Alendronate prevents steroid-induced osteoporosis in patients with rheumatic diseases].

Abstract

OBJECTIVE:

To investigate the effects of alendronate (Alen) on the prevention of systemic glucocorticoid-induced osteoporosis in patients with rheumatic diseases.

METHODS:

140 patients suffering from rheumatic diseases, including systemic lupus erythematosus, polymyositis, dermatomyositis, and Sjögren's syndrome, with normal bone mineral density (BMD) and treated with oral glucocorticoids were randomly divided into 2 groups: Alen + calcium group (n = 74) receiving Alen 10 mg once a day and castrate D 600 0.6 g once a day for 24 weeks and control group (n = 66) receiving castrate D 600 0.6 g once a day for 24 weeks. The BMD and biomarkers of bone turnover were measured at baseline and 24 weeks after initiating glucocorticoid therapy.

RESULTS:

After 24 weeks, the BMD values at lumbar spine, femoral neck, major trochanter, and Ward' s triangle increased by 6.1%, 6.3%, 3.3%, and 2.2% respectively compared with those at baseline (all P<0.05), however, those of the control group decreased by 8.7%, 9.1%, 7.7%, and 6.4% respectively (P<0.01, P<0.05), and the BMD levels at lumbar spine and femoral neck 24 weeks later of the Alen + calcium group were both higher than those of the control group (P<0.01, P<0.05). 24 weeks later the level of urine cross linked N-telopeptides of type I collagen (NTX) of the Alen + calcium group decreased (P<0.05), and the blood osteocalcin (BGP) of the Alen + calcium group increased, however, not significantly (P>0.05). There were no significant differences in serum AKP and BGP and urine NTX 24 weeks later between these 2 groups.

CONCLUSION:

Improving BMD, alendronate plays an important role in the prevention of glucocorticoid-induced osteoporosis. However, calcium treatment alone fails to prevent the loss of bone.

• Authors: Qiao-hong Wang, Hua-xiang Wu, Yong-lu Huang, Jing Xue, Xu-yan Yang, Liang Zhu, Li-hong Wen
• Journal: Zhonghua yi xue za zhi (Zhonghua Yi Xue Za Zhi) Vol. 88 Issue 27 Pg. 1888-91 (Jul 15 2008) ISSN: 0376-2491 [Print] China
• PMID: 19040000 (Publication Type: English Abstract, Journal Article, Randomized Controlled Trial)

Chemical References

• Bone Density Conservation Agents
• Glucocorticoids
• Alendronate

Topics

• Adult
• Alendronate (therapeutic use)
• Bone Density (drug effects)
• Bone Density Conservation Agents (therapeutic use)
• Female
• Glucocorticoids (adverse effects, therapeutic use)
• Humans
• Lupus Erythematosus, Systemic (drug therapy)
• Male
• Middle Aged
• Osteoporosis (chemically induced, physiopathology, prevention & control)
• Rheumatic Diseases (drug therapy)
• Treatment Outcome
• Young Adult