Abstract | AIM: METHODS: RESULTS: After cerebral ischemia- reperfusion damage, the neurologic deficit score and the infarct volume percentage in treatment group were significantly lower than in the model group (P<0.01). Micro-positive emission tomography imaging showed that glucose metabolism in the right temporal lobe and the right frontal lobe were significantly decreased in the model group in comparison with the sham operation group (P<0.01). After treatment, glucose metabolism increased significantly in the puerarin group and the chuanxiongzine- puerarin group, compared with the model group (P<0.05 and <0.01, respectively). The expression of interleukin-1beta-mRNA was significantly higher in the model group than in the sham operation group (P<0.01). After treatment, however, it was significantly decreased in the puerarin group (P<0.05) and the chuanxiongzine- puerarin group (P<0.01) compared with the model group. SOD activity in the model group (P<0.01) was lower than that in the sham operation group, whereas MDA and NO content in the model group was more than that in the sham operation group (P<0.01). In the chuanxiongzine- puerarin and puerarin treatment groups, SOD activity showed higher level compared with the model group (P<0.01); however, MDA and NO content was decreased in the treatment group (P<0.01). Synaptophysin level was significantly lower in the model group compared with the sham operation group (P<0.01), whereas the chuanxiongzine- puerarin and puerarin groups showed significantly higher values than the model group (P<0.05). CONCLUSION:
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Authors | Haitong Wan, Huiyuan Zhu, Mei Tian, Xiaolei Hu, Jiehong Yang, Chunlei Zhao, Hong Zhang |
Journal | Nuclear medicine communications
(Nucl Med Commun)
Vol. 29
Issue 12
Pg. 1113-22
(Dec 2008)
ISSN: 0143-3636 [Print] England |
PMID | 18987534
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Antioxidants
- Interleukin-1
- Isoflavones
- Neuroprotective Agents
- Pyrazines
- Synaptophysin
- Tetrazolium Salts
- Nitric Oxide
- Malondialdehyde
- triphenyltetrazolium
- Superoxide Dismutase
- Glucose
- tetramethylpyrazine
- puerarin
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Topics |
- Animals
- Antioxidants
(pharmacology)
- Brain
(drug effects, metabolism, pathology)
- Gene Expression Regulation
(drug effects)
- Glucose
(metabolism)
- Infarction, Middle Cerebral Artery
(complications)
- Interleukin-1
(genetics)
- Ischemic Attack, Transient
(diagnosis, etiology, metabolism, pathology)
- Isoflavones
(pharmacology)
- Male
- Malondialdehyde
(metabolism)
- Nervous System Diseases
(complications)
- Neuroprotective Agents
(pharmacology)
- Nitric Oxide
(metabolism)
- Pyrazines
(pharmacology)
- Rats
- Rats, Sprague-Dawley
- Reperfusion Injury
(diagnosis, etiology, metabolism, pathology)
- Superoxide Dismutase
(metabolism)
- Synaptophysin
(metabolism)
- Tetrazolium Salts
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