Potential chemoprevention effect of dietary fucoxanthin on urinary bladder cancer EJ-1 cell line.

Abstract

Bladder cancer is a common but serious malignancy. It is widely accepted that chemoprevention may be an effective way to decrease the rate of recurrence and morbidity. We first determined antigrowth and apoptosis-induction activity of fucoxanthin from dietary Laminaria japonica against EJ-1 human bladder cancers. Fucoxanthin significantly reduced the cell viability in a dose- and time-dependent manner. The induction of apoptosis in EJ-1 cells was characterized by morphological changes, DNA ladder, and increased percentage of hypodiploid cells, activating caspase-3 activity. The ratio of apoptotic cells reached >93% after treatment for 72 h with 20 microM fucoxanthin. The findings obtained indicate that fucoxanthin may act as a chemopreventive and/or chemotherapeutic carotenoid in bladder cancer cells by modulating cell viability.

• Authors: Zhenya Zhang, Peijuan Zhang, Michito Hamada, Satoru Takahashi, Guoqing Xing, Jiqiang Liu, Norio Sugiura
• Journal: Oncology reports (Oncol Rep) Vol. 20 Issue 5 Pg. 1099-103 (Nov 2008) ISSN: 1021-335X [Print] Greece
• PMID: 18949407 (Publication Type: Journal Article)

Chemical References

• Antineoplastic Agents
• Reactive Oxygen Species
• Xanthophylls
• fucoxanthin

Topics

• Antineoplastic Agents (pharmacology)
• Apoptosis (drug effects)
• Cell Line, Tumor
• Cell Survival (drug effects)
• Chemoprevention
• Diet
• Flow Cytometry
• Humans
• Reactive Oxygen Species
• Urinary Bladder Neoplasms (prevention & control)
• Xanthophylls (pharmacology)