Abstract |
We measured 8-isoprostane, a biomarker of oxidative stress, and prostaglandin (PG) E(2) in exhaled breath condensate in 36 stable and 14 unstable cystic fibrosis (CF) patients, and in 15 healthy age-matched controls. We studied the relationships of these eicosanoids with clinical, radiological, and systemic inflammatory parameters. Compared with controls [15.5 (11.5-17.0) pg/ml] exhaled 8-isoprostane was increased in stable CF patients [30.5 (25.3-36.0) pg/ml, P<0.001]. Unstable CF patients had higher exhaled 8-isoprostane levels [47.5 (44.0-50.0) pg/ml, P<0.001] than stable CF patients. Unlike PGE(2), exhaled 8-isoprostane was negatively correlated with FEV(1) (r=-0.67; P<0.0001; r=-0.63; P<0.02) and Shwachman score (r=-0.43, P=0.012; r=-0.58, P=0.031) and positively correlated with Chrispin-Norman score (r=0.51, P<0.002; r=0.56, P=0.039) in stable and unstable CF patients, respectively. No correlation was observed with C-reactive protein. Compared with controls [41.0 (29.0-50.0) pg/ml], exhaled PGE(2) was also elevated in stable [72.0 (64.3-81.8) pg/ml, P<0.001) and, to a greater extent, in unstable CF patients [83.0 (74.3-91.3) pg/ml, P<0.001). In patients with CF, exhaled 8- isoprostane and PGE(2) could be a useful marker of disease severity.
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Authors | Vincenzina Lucidi, Giovanni Ciabattoni, Sergio Bella, Peter J Barnes, Paolo Montuschi |
Journal | Free radical biology & medicine
(Free Radic Biol Med)
Vol. 45
Issue 6
Pg. 913-9
(Sep 15 2008)
ISSN: 0891-5849 [Print] United States |
PMID | 18634869
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- 8-epi-prostaglandin F2alpha
- C-Reactive Protein
- Dinoprost
- Dinoprostone
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Topics |
- Breath Tests
- C-Reactive Protein
(metabolism)
- Child
- Cross-Sectional Studies
- Cystic Fibrosis
(blood, metabolism, physiopathology)
- Dinoprost
(analogs & derivatives, metabolism)
- Dinoprostone
(metabolism)
- Female
- Humans
- Leukocyte Count
- Male
- Respiratory Function Tests
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