Abstract | OBJECTIVES: To compare abomasal emptying rates in calves after suckling milk replacer or 3 common orally administered electrolyte solution components. ANIMALS: 5 male calves < 35 days of age. PROCEDURES: Calves with a cannula fitted in the abomasal body were fed 2 L of milk replacer with or without parenteral administration of atropine (0.01 mg/kg, i.v., then 0.02 mg/ kg, s.c., q 30 min) or isotonic (150 mM) solutions of sodium acetate, NaHCO(3), or NaCl in a randomized crossover design. Abomasal emptying rates were determined via scintigraphy, acetaminophen absorption, ultrasonography, and change in abomasal luminal pH. RESULTS: Scintigraphic half-emptying time, time of maximal plasma acetaminophen concentration, ultrasonographic half-emptying time, and pH return time indicated similar abomasal emptying rates following suckling of isotonic sodium acetate, NaHCO(3), and NaCl solutions, whereas the emptying rate of milk replacer was significantly slower. Mean maximal abomasal luminal pH was highest following suckling of NaHCO(3) (pH(max)=7.85) and lowest following suckling of NaCl (pH(max)=4.52); sodium acetate (pH(max)=6.59) and milk replacer (pH(max)=5.84) yielded intermediate pH values. CONCLUSIONS AND CLINICAL RELEVANCE:
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Authors | Tessa S Marshall, Peter D Constable, Sonia S Crochik, Thomas Wittek, David E Freeman, Dawn E Morin |
Journal | American journal of veterinary research
(Am J Vet Res)
Vol. 69
Issue 6
Pg. 824-31
(Jun 2008)
ISSN: 0002-9645 [Print] United States |
PMID | 18518665
(Publication Type: Comparative Study, Journal Article, Research Support, U.S. Gov't, Non-P.H.S.)
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Chemical References |
- Rehydration Solutions
- Acetaminophen
- Sodium Chloride
- Sodium Acetate
- Sodium Bicarbonate
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Topics |
- Abomasum
(diagnostic imaging, metabolism)
- Acetaminophen
(pharmacology)
- Animals
- Animals, Suckling
- Cattle
(physiology)
- Cross-Over Studies
- Gastric Emptying
(drug effects)
- Hydrogen-Ion Concentration
- Male
- Radionuclide Imaging
(veterinary)
- Random Allocation
- Rehydration Solutions
(pharmacology)
- Sodium Acetate
(pharmacology)
- Sodium Bicarbonate
(pharmacology)
- Sodium Chloride
(pharmacology)
- Ultrasonography
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