State-dependent changes in the expression levels of NCAM-140 and L1 in the peripheral blood cells of bipolar disorders, but not in the major depressive disorders.

Abstract

Recent postmortem brain and imaging studies provide evidence for disturbances of structural and synaptic plasticity in patients with mood disorders. Several lines of evidence suggest that the cell adhesion molecules (CAMs), neural cell adhesion molecules (NCAM) and L1, play important roles in both structural and synaptic plasticity. Although postmortem brain studies have indicated altered expression levels of NCAM and L1, it is still unclear whether these changes are state- or trait-dependent. In this study, the mRNA levels for various CAMs, including NCAM and L1, were measured using quantitative real-time PCR in peripheral blood cells of major depressive disorder patients, bipolar disorder patients and normal healthy subjects. Reduced expression levels of NCAM-140 mRNA were observed in bipolar disorder patients in a current depressive state. In contrast, L1 mRNA levels were increased in bipolar disorder patients in a current depressive state. NCAM-140 and L1 mRNA levels were not changed in bipolar disorder patients in a remissive state, or in major depressive disorder patients. In addition, there were no significant changes in the expression levels of intercellular adhesion molecule -1, vascular cell adhesion molecule -1, E-cadherin, or integrin alphaD among healthy controls, major depressive or bipolar disorder patients. Our results suggest that the reciprocal alteration in the expression of NCAM-140 and L1 mRNAs could be state-dependent and associated with the pathophysiology of bipolar disorder.

• Authors: Yusuke Wakabayashi, Shusaku Uchida, Hiromasa Funato, Toshio Matsubara, Toshio Watanuki, Koji Otsuki, Michiko Fujimoto, Akira Nishida, Yoshifumi Watanabe
• Journal: Progress in neuro-psychopharmacology & biological psychiatry (Prog Neuropsychopharmacol Biol Psychiatry) Vol. 32 Issue 5 Pg. 1199-205 (Jul 01 2008) ISSN: 0278-5846 [Print] England
• PMID: 18430502 (Publication Type: Comparative Study, Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Antidepressive Agents
• Cell Adhesion Molecules, Neuronal
• NCAM140, human
• Neural Cell Adhesion Molecule L1
• RNA, Messenger
• Dexamethasone
• Corticotropin-Releasing Hormone
• Hydrocortisone

Topics

• Analysis of Variance
• Antidepressive Agents (therapeutic use)
• Bipolar Disorder (blood, drug therapy)
• Blood Cells (metabolism)
• Cell Adhesion Molecules, Neuronal (genetics, metabolism)
• Corticotropin-Releasing Hormone (blood)
• Depressive Disorder, Major (blood, drug therapy)
• Dexamethasone
• Female
• Follow-Up Studies
• Gene Expression Regulation (physiology)
• Humans
• Hydrocortisone (blood)
• Male
• Middle Aged
• Neural Cell Adhesion Molecule L1 (genetics, metabolism)
• RNA, Messenger (metabolism)
• Radioimmunoassay
• Time Factors