Insulinoma and gastrinoma syndromes from a single intrapancreatic neuroendocrine tumor.

Abstract

CONTEXT:

The insulinoma syndrome is marked by fasting hypoglycemia and inappropriate elevations of insulin. The gastrinoma syndrome is characterized by hypergastrinemia, ulcer disease, and/or diarrhea. Rarely, insulinoma and gastrinoma coexist in the same patient simultaneously.

OBJECTIVE:

Our objective was to determine the cause of a patient's hypoglycemic episodes and peptic ulcer disease.

DESIGN AND SETTING:

This is a clinical case report from the Clinical Research Center of the National Institutes of Health.

PATIENT AND INTERVENTION:

One patient with hypoglycemic episodes and peptic ulcer disease had a surgical resection of neuroendocrine tumor.

RESULTS:

The patient was found to have a single tumor cosecreting both insulin and gastrin. Resection of this single tumor was curative.

CONCLUSIONS:

A single pancreatic neuroendocrine tumor may lead to the expression of both the hyperinsulinemic and hypergastrinemic syndromes.

• Authors: Maya B Lodish, Anathea C Powell, Mones Abu-Asab, Craig Cochran, Petra Lenz, Steven K Libutti, James F Pingpank, Maria Tsokos, Phillip Gorden
• Journal: The Journal of clinical endocrinology and metabolism (J Clin Endocrinol Metab) Vol. 93 Issue 4 Pg. 1123-8 (Apr 2008) ISSN: 0021-972X [Print] United States
• PMID: 18252785 (Publication Type: Case Reports, Journal Article, Research Support, N.I.H., Intramural)

Chemical References

• Gastrins
• Insulin

Topics

• Adolescent
• Female
• Gastrinoma (etiology)
• Gastrins (blood)
• Humans
• Insulin (blood)
• Insulinoma (etiology)
• Neuroendocrine Tumors (metabolism, surgery)
• Pancreatic Neoplasms (etiology, metabolism)
• Syndrome