Abstract | BACKGROUND AND AIM: METHODS: RESULTS: Eight weeks after the cessation of TAA administration, spleen weight, histological score of liver fibrosis, and hepatic hydroxyproline content were significantly lower in both groups of hypothyroid rats as compared to euthyroid controls (P < 0.001). In vitro studies using the rat hepatic stellate cell line HSC-T6 using northern blot analysis and zymography, respectively, showed that high concentrations of triiodotyronine (T(3)) enhanced transforming growth factor ( TGF)-beta-induced collagen I gene expression, and reduced metalloproteinase (MMP)-2 secretion, implying that reducing the levels of T(3) may contribute to resolution of fibrosis. Additionally, low T(3) concentration inhibited HSC-T6 proliferation. CONCLUSION: Pharmacologically induced hypothyroidism accelerates the resolution of liver fibrosis in rats. This beneficial effect may in part be due to prevention of T(3)-induced stimulation of collagen synthesis and reduction of MMP-2 secretion.
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Authors | Rafael Bruck, Sigal Weiss, Alexandra Traister, Isabel Zvibel, Hussein Aeed, Zamir Halpern, Ran Oren |
Journal | Journal of gastroenterology and hepatology
(J Gastroenterol Hepatol)
Vol. 22
Issue 12
Pg. 2189-94
(Dec 2007)
ISSN: 0815-9319 [Print] Australia |
PMID | 18031379
(Publication Type: Journal Article)
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Chemical References |
- Collagen Type I
- Transforming Growth Factor beta
- Triiodothyronine
- Matrix Metalloproteinase 2
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Topics |
- Animals
- Cell Line
- Cell Proliferation
(drug effects)
- Collagen Type I
(genetics, metabolism)
- Gene Expression Regulation
(drug effects)
- Hepatocytes
(cytology, drug effects, enzymology, metabolism)
- Hypothyroidism
(chemically induced, complications)
- Liver
(drug effects, metabolism, pathology)
- Liver Cirrhosis
(complications)
- Male
- Matrix Metalloproteinase 2
(metabolism)
- Rats
- Rats, Wistar
- Transforming Growth Factor beta
(pharmacology)
- Triiodothyronine
(pharmacology)
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