Abstract | INTRODUCTION: Children in Singapore receive vaccination against hepatitis B virus (HBV) at 0, 1 and 5 or 6 months of age, and vaccination against pertussis, diphtheria, tetanus, and polio at 3, 4 and 5 months of age. Parents often choose to vaccinate with the combined acellular- pertussis-inactivated polio-Hib vaccine ( DTPa-IPV/Hib). We investigated whether a combined hexavalent vaccine, DTPa-HBV-IPV/Hib, could replace the separate administration of DTPa-IPV/Hib and HBV for the final vaccination at 5 months of age (Trial DTPa-HBV-IPV-075). MATERIALS AND METHODS: In an open study, 150 children were randomised to complete their vaccination schedule with DTPa-IPV/Hib + HBV or DTPa-HBV-IPV/Hib. RESULTS: One month after the final vaccination, there was no difference between groups in seroprotection rates or antibody concentrations against HBV. Seroprotection rates against diphtheria, tetanus, Hib and polio, as well as vaccine response rates to pertussis antigens were also similar between groups. Local and general symptoms occurred at a similar rate after the third dose of either vaccine. CONCLUSION:
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Authors | Fong Seng Lim, Htay-Htay Han, Jeanne-Marie Jacquet, Hans L Bock |
Journal | Annals of the Academy of Medicine, Singapore
(Ann Acad Med Singap)
Vol. 36
Issue 10
Pg. 801-6
(Oct 2007)
ISSN: 0304-4602 [Print] Singapore |
PMID | 17987229
(Publication Type: Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)
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Chemical References |
- DTP-IPV-Hib vaccine
- Diphtheria-Tetanus-Pertussis Vaccine
- Haemophilus Vaccines
- Hepatitis B Antibodies
- Hepatitis B Vaccines
- Poliovirus Vaccine, Inactivated
- Vaccines, Combined
- Vaccines, Inactivated
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Topics |
- Diphtheria
(immunology)
- Diphtheria-Tetanus-Pertussis Vaccine
- Female
- Haemophilus Vaccines
- Haemophilus influenzae
(immunology)
- Hepatitis B
(prevention & control)
- Hepatitis B Antibodies
(blood)
- Hepatitis B Vaccines
(administration & dosage)
- Humans
- Immunization Schedule
- Infant
- Infant, Newborn
- Male
- Poliovirus Vaccine, Inactivated
- Singapore
- Tetanus
(immunology)
- Vaccination
- Vaccines, Combined
(administration & dosage)
- Vaccines, Inactivated
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