Poliomyelitis (Polio)

Subscribe to Selected New Research on Poliomyelitis

3502 relevant articles (84 outcomes, 291 trials/studies) found for this Disease

Description: An acute infectious disease of humans, particularly children, caused by any of three serotypes of human poliovirus (POLIOVIRUS). Usually the infection is limited to the gastrointestinal tract and nasopharynx, and is often asymptomatic. The central nervous system, primarily the spinal cord, may be affected, leading to rapidly progressive paralysis, coarse FASCICULATION and hyporeflexia. Motor neurons are primarily affected. Encephalitis may also occur. The virus replicates in the nervous system, and may cause significant neuronal loss, most notably in the spinal cord. A rare related condition, nonpoliovirus poliomyelitis, may result from infections with nonpoliovirus enteroviruses. (From Adams et al., Principles of Neurology, 6th ed, pp764-5)

Also Known As:

Polio; Infantile Paralysis; Paralysis, Infantile; Polios; Encephalitis, Polio; Epidemic Acute Poliomyelitis; Polio Encephalitis; Poliomyelitis, Acute; Acute Poliomyelitis; Acute Poliomyelitis, Epidemic; Nonpoliovirus Poliomyelitis; Poliomyelitides, Preparalytic; Poliomyelitis, Epidemic Acute; Preparalytic Poliomyelitis; Poliomyelitis, Nonpoliovirus; Poliomyelitis, Preparalytic

Relationship Network

Disease Context: Research Results

Virus Diseases: 1376

RNA Virus Infections: 46

Picornaviridae Infections: 39

Enterovirus Infections: 161

Poliomyelitis: 3502

Postpoliomyelitis Syndrome: 56

Bulbar Poliomyelitis: 33

Central Nervous System Viral Diseases: 10

Poliomyelitis: 3502

Myelitis: 266

Poliomyelitis: 3502

Postpoliomyelitis Syndrome: 56

Bulbar Poliomyelitis: 33

Related Diseases

1.	Measles
2.	Tetanus
3.	Whooping Cough (Pertussis)
4.	Infection
5.	Diphtheria

Experts

1.	Schuerman, Lode: 5 articles (08/2008 - 12/2004)
2.	Neyts, Johan: 3 articles (09/2008 - 04/2008)
3.	García-Corbeira, Pilar: 3 articles (01/2007 - 12/2004)
4.	Borg, Kristian: 2 articles (10/2008 - 05/2004)
5.	Andries, Koen: 2 articles (06/2008 - 04/2008)
6.	Rombaut, Bart: 2 articles (06/2008 - 04/2008)
7.	De Palma, Armando M: 2 articles (06/2008 - 04/2008)
8.	Gromeier, Matthias: 2 articles (02/2008 - 09/2004)
9.	Cello, Jeronimo: 2 articles (02/2008 - 08/2002)
10.	Wimmer, Eckard: 2 articles (02/2008 - 08/2002)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Poliomyelitis:

1.	VaccinesIBA 12/01/1986 - "However, simultaneous administration of polio and RIT 4237 vaccines caused a significant reduction of the antibody response to rotavirus but not to polioviruses types 1 and 3." 01/01/2009 - "CONCLUSIONS: The use of cool water packs is found to be a legitimate and safe practice for vaccines other than oral polio vaccine, so that cool water packs can safely replace frozen icepacks without any serious consequences on the ability of vaccines to confer protection against disease." 01/01/1992 - "Presently available polio vaccines may prove very useful for progress with polio control, provided the prevention programme has been adequately chosen and the limitations of the vaccine used have been taken into consideration. " 05/01/1965 - "[Studies on the immunologic efficacy of live polio vaccines and propagation of the vaccine viruses. " 05/01/1965 - "[Studies on the immunologic efficacy of live polio vaccines and propagation of the vaccine viruses. " Order ALL the reference details at left...
2.	alpha-Fetoproteins (AFP)IBA 01/01/1994 - "As the prevalence of wild poliovirus declines in China, reliable laboratory support needs to be established and adequately sensitive and specific AFP surveillance be developed if poliomyelitis is to be eradicated." 12/03/2004 - "As poliomyelitis is eradicated, AFP surveillance systems in these and other countries might be further expanded and adapted to improve the detection of and response to other diseases." 02/01/1997 - "Through the development of AFP surveillance, polio eradication also helped to improve surveillance for other Expanded Programme on Immunization diseases." 01/01/1993 - "The role of AFP surveillance and investigation of suspected cases are discussed in the light of the need to establish that poliomyelitis has been eliminated." 07/01/2009 - "CONCLUSIONS: This study provided definitive information about circulation, prevalence and new emerging NPEV in the polio-endemic region of India, hence they should be considered in AFP surveillance. " Order ALL the reference details at left...
3.	Oral Poliovirus Vaccine (Sabin Vaccine)IBA 04/12/2007 - "BACKGROUND: After poliomyelitis has been eradicated, access to live polioviruses will be highly restricted and the use of oral poliovirus vaccine (OPV) will probably be discontinued. " 05/01/1984 - "Oral poliovirus vaccine administered during the first year of life has been effective in controlling poliomyelitis in tropical Africa." 10/01/1984 - "The present study showed that the neurovirulence test for the lesion-inducing virus dose in the spinal cord in 50% of monkeys inoculated with oral polio-vaccine (Sabin) (LID50) reflected to a large extent safety and efficacy of the vaccine upon administration to children. " 01/01/1981 - "Field trial on the efficacy of oral Sabin vaccine versus Salk polio vaccine." 09/28/2007 - "However, because vaccine-derived polioviruses (VDPVs) can produce polio outbreaks in areas with low rates of Sabin oral poliovirus vaccine (OPV) coverage and can replicate for years in immunodeficient persons, enhanced strategies are needed to limit emergence of VDPVs and stop all use of OPV once WPV transmission is eliminated. " Order ALL the reference details at left...
4.	Inactivated Poliovirus Vaccine (Salk Vaccine)IBA 01/01/2004 - "There are further uncertainties concerning the possible role and efficacy of inactivated poliovirus vaccine (IPV) used either routinely or in outbreak control in low-hygiene settings, the potential for rapid geographical spread of polioviruses should an outbreak occur after certification, and the risks inherent in introducing additional oral polio vaccine (OPV) viruses into populations in which the vaccine coverage and prevalence of immunity have declined, and which may thus favour the spread of VDPVs. " 04/15/1999 - "The inactivated poliovirus vaccine (IPV) is used for protection against poliomyelitis in The Netherlands. " 09/01/1997 - "In The Netherlands the inactivated poliovirus vaccine (IPV) is used for protection against poliomyelitis. " 12/01/1991 - "Inactivated poliovirus vaccine (IPV) is the vaccine of choice for protection against paralytic poliomyelitis provided that it is used within the context of a program to increase and sustain the level of uptake to as close to 100% as possible. " 04/23/1988 - "The 1986-87 outbreak of paralytic poliomyelitis in Senegal, with 676 reported cases, provided an opportunity to evaluate the efficacy of an enhanced-potency inactivated poliovirus vaccine (N-IPV) in the Kolda region, where this vaccine has been used since 1980. " Order ALL the reference details at left...
5.	AntibodiesIBA 02/01/1996 - "Assuming as unprotected those individuals without detectable neutralizing antibodies at the dilution 1:2, nobody resulted without protection against all types of poliovirus; 0.7% lacked antibodies only against type 1, 0.6% only against type 3 and none against type 2. A very slight decreasing trend was observed for GMT values in function of the distance from the last dose of OPV for polio 1 and 2, but not for polio 3. As expected, GMT values for polio 2 resulted higher than those for polio 1 and both were higher than those for polio 3, when calculated by age groups as well as by distance groups. " 08/01/1995 - "The vaccine efficacy against poliomyelitis was 96% for serotype I, 100% for serotype II and 97-98% for serotype III. Of the infants in both groups, 97% had antibodies against B. " 05/05/2009 - "This study evaluated the seroprevalence of poliovirus types 1, 2 and 3 antibodies and vaccination coverage in 780 subjects aged between 7 months and 39 years in Montevideo, Uruguay, where oral polio vaccine (OPV) is used. " 05/01/2007 - "Studies of strain-specific antibodies to vaccine and wild viruses of poliomyelitis in donors from 4 towns established that the immune persons were more in the town where wild polioviruses had previously circulated than in those where the circulation of wild polioviruses had been limited and immunity resulted from vaccination. " 01/01/2007 - "The persistence of poliovirus-neutralizing antibodies was investigated in 297 individuals residing in Argentina who had completed the vaccination cycle with four or five oral polio vaccine (OPV) doses 1 mo to 19 yr before this study. " Order ALL the reference details at left...
6.	Diphtheria-Tetanus-Pertussis Vaccine (DPT Vaccine)IBA 07/01/1962 - "Studies on combined adsorbed poliomyelitis-DTP vaccine. " 01/01/2001 - "During the interval between the cessation of wild virus transmission and the global stoppage of polio vaccination, it will be advantageous to use IPV, particularly combined with DPT vaccine, to provide individual protection, and herd effect to prevent spread in case of the introduction of wild polioviruses, whether unintentionally or otherwise, and to bolster the Expanded Programme on Immunisation." 11/01/1993 - "The proportions of infants on whom immunisation was initiated, were very high for DPT vaccine (88-99%) and polio vaccine (85-99%); however, of those who had received the first dose, 23-39 per cent did not complete the 3-dose schedule. " 04/01/1990 - "Up to 91.25% children had received four doses of polio vaccine and 94.67% three doses, while 91.63% had received four doses of DTP vaccine and 95.06% three doses. " 02/01/1969 - "Mouse toxicity of triple vaccine (DTP) mixed with poliomyelitis vaccine." Order ALL the reference details at left...
7.	UniversalIBA 03/01/1990 - "In cord blood, 83.3% had a NT titre greater than or equal to 4 and 99.0% had a titre greater than or equal to 2. Similarly, by one year of age, 85.7% had a titre greater than or equal to 4 and 90.5% had a titre greater than or equal to 2. Seropositivity to PV-2 and PV-3 were slightly lower, ie 80.8% of children had a PV-2 titre greater than or equal to 4 and 75.4% had a PV-3 titre greater than or equal to 4. As for other developing areas, poliomyelitis eradication in Gaza will come about when universal vaccination fills all 'immunity gaps' and improved sanitation and housing reduces the endemicity of wild polioviruses." 12/15/2008 - "However, new information that has been learned about poliovirus, as well as the political realities of a modern world, demand that universal immunity against poliomyelitis be maintained, even after wild-type poliovirus is eradicated. " 10/01/2008 - "Universal immunization program and polio eradication in India." 11/01/2006 - "Universal use of inactivated polio vaccine." 07/01/2006 - "Universal use of inactivated polio vaccine." Order ALL the reference details at left...
8.	AntigensIBA 10/07/1963 - "AN IMPROVED METHOD FOR CONCENTRATING AND PURIFYING POLIO ANTIGEN WITH THE MIXED BED ION EXCHANGER (BRIEF REPORT)]" 12/01/2004 - "RESULTS: Polio and non-polio antigen coverage increased in seven countries during the study period. " 01/01/1979 - "Study of the HLA antigen in Arab children with paralytic poliomyelitis." 11/01/1964 - "[STUDIES ON THE MECHANISM OF DEVELOPMENT OF A NON-INFECTIVE "ACRIDINE" POLIO-ANTIGEN.]" 01/01/1962 - "[Study of the stability of the poliomyelitis antigen in tetravalent vaccine.]" Order ALL the reference details at left...
9.	Poliovirus VaccinesIBA 01/01/1980 - "Poliovirus vaccines (Salk-type and Sabin-type) have virtually eliminated paralytic poliomyelitis. " 08/01/1998 - "OBJECTIVE: To study the effect of an educational videotape about poliovirus vaccines and choices of schedules for parents/guardians of children starting the polio vaccination series. " 10/16/2008 - "BACKGROUND: The number of cases of paralytic poliomyelitis has declined in Nigeria since the introduction of newly licensed monovalent oral poliovirus vaccines and new techniques of vaccine delivery. " 03/28/2008 - "Use of intense poliomyelitis eradication measures, including close coordination between the two countries and increased use of monovalent oral poliovirus vaccines (mOPVs) against type 1 WPV (WPV1) and type 3 WPV (WPV3), has reduced WPV transmission to historically low levels. " 12/01/2006 - "In addition, continued vaccination with oral poliovirus vaccines would result in the continued occurrence of vaccine-associated paralytic poliomyelitis. " Order ALL the reference details at left...
10.	Attenuated VaccinesIBA 01/01/2006 - "SIGNIFICANCE: VDPVs that revert from live oral attenuated vaccines and reacquire characteristics of wild-type polioviruses not only threaten populations with poor immune coverage, but are also a potential source for re-introduction of poliomyelitis into highly immune populations through older individuals with waning immunity. " 05/01/2005 - "A higher protection was observed in the case of live attenuated vaccines (oral poliomyelitis and bacilli Camille-Guerin; OR = 0.26; 95% CI: 0.08, 0.83). " 06/01/2004 - "In the history of virus vaccine, live attenuated vaccines have been proved most effective in measles and polio-myelitis. " 11/01/1990 - "The live attenuated vaccines against poliomyelitis developed by Sabin are among the safest and most effective antiviral vaccines in current use and have eliminated poliomyelitis as a public health problem in many countries. " 02/01/1993 - "In contrast, morbidity must be expected if live attenuated vaccines (oral polio vaccine, attenuated measles vaccine or attenuated varicella vaccine) are administered to children receiving anti-cancer therapy. " Order ALL the reference details at left...

Therapies and Procedures

1.	Injections 05/01/1984 - "Injectable polio vaccine, although found to be highly effective in routine immunization programs, is very costly and in short supply. " 04/01/2003 - "Our study confirms that injections administered during the poliovirus incubation period can provoke paralytic poliomyelitis. " 03/01/1992 - "This study confirms that injections are an important cause of provocative poliomyelitis. " 01/01/1991 - "The results of the study of postvaccinal immunity to poliomyelitis suggest that during the first and second year of life the course of vaccination against poliomyelitis may be reduced to 3 injections." 04/01/2003 - "Injections in polio-endemic countries should only be indicated when other therapeutic options have failed or are not available." Order ALL the reference details at left...
2.	Transplantation (Transplant Recipients) 08/01/1959 - "[Physiological studies of the remote results of tendon and muscle transplantation in poliomyelitis.]" 01/01/2002 - "Shoulder fusion and free-functioning gracilis transplantation for biceps replacement provide a solution for restoration of function in children with flail shoulder and elbow, as caused by poliomyelitis. " 10/01/1991 - "Immune response to polio vaccination in bone marrow transplant recipients." 02/01/1991 - "Response to immunization against polio after allogeneic marrow transplantation." 09/01/1966 - "[Transplantation of the extensor muscles of the toes onto the metatarsal bones in the treatment of the poliomyelitis foot]" Order ALL the reference details at left...
3.	Resistance Training 03/01/2003 - "We therefore conclude that moderate intensity strength training is safe and effective in post-polio patients." 03/01/2003 - "The purpose of this study was to test the hypotheses that: (1) after strength training, post-polio patients show strength improvement comparable to that seen in the healthy elderly; (2) such training does not have a deleterious effect on motor unit (MU) survival; and (3) part of the strength improvement is due to an increase in voluntary motor drive. " 03/01/2003 - "Randomized controlled trial of strength training in post-polio patients." 10/01/2008 - "Effects of resistance training in combination with coenzyme Q10 supplementation in patients with post-polio: a pilot study." Order ALL the reference details at left...
4.	Arthroplasty 12/01/2009 - "We performed a retrospective chart and radiograph review of 10 patients with a history of poliomyelitis involving a limb that subsequently underwent primary total knee arthroplasty between 2000 and 2008. " 12/01/2009 - "Total knee arthroplasty in patients with poliomyelitis." 06/01/2009 - "Importance of neurological evaluation before reverse shoulder arthroplasty in patients with previous poliomyelitis." 01/01/2009 - "Unicondylar knee arthroplasty in a patient with poliomyelitis." 06/01/2007 - "A conversion total hip arthroplasty using a 58-mm cementless shell and screws and constrained acetabular liner was performed in a 71-year-old patient with a nonunion of an intertrochanteric fracture and poliomyelitis with flail extremities. " Order ALL the reference details at left...
5.	Fluid Therapy (Oral Rehydration Therapy) 08/05/1982 - " Poliomyelitis and tuberculosis prevention campaigns are likewise effective and oral rehydration centers have been set up to combat infant diarrhea. " 04/01/1998 - ""Child Survival Activities in Turkey" are: growth monitoring programs, expanded programs of immunization (elimination of neonatal tetanus, reducing morbidity and mortality of measles, eradication of polio), control of diarrheal diseases (oral rehydration therapy), control of deaths from pneumonia (ARI), baby-friendly hospitals initiative and promotion of breast-feeding, salt iodization programs, elimination of vitamin A deficiency, safe motherhood projects, and phenylketonuria screening programs. " 03/01/1987 - "UNICEF-supported work (GOBI/FFF) has proposed to early childhood mortality and disease which are free, relevant and available: 1) growth mortality, which can expose malnutrition before it's too late; 2) oral rehydration therapy for diarrhea which is a major killer and is remedied by rehydration salts; 3) breast feeding, which provides immunity, nutrition at low cost, and warmth, and security, and 4) immunization from measles, TB, diphtheria, tetanus, polio, and whooping cough. " 10/01/1997 - " Moreover, the deaths of over 1 million children annually are being averted through the increased use of oral rehydration therapy against diarrheal dehydration, poliomyelitis and guinea worm have almost been eradicated, the consumption of iodized salt is protecting approximately 12 million infants annually from iodine deficiency, and access to safe drinking water is on the rise. " 06/01/1991 - "The adjuvanticity of liposomes on two different modes of presentation of polio virus subunit peptides was demonstrated by incorporating the poorly immunogenic synthetic polio peptides, W1 and W2, into the internal space of and covalently-linked to the surface of dehydration-rehydration vesicles (DRV). " Order ALL the reference details at left...

Best Treatments:
Research Summary Report
on Poliomyelitis

CureHunter Patient-Physician Summary Reports collect in one document all the medications ever reported in the US National Library of Medicine—1949 to the present—to be effective against your target disease. CureHunter research summary reports will vary in length from 25 to 250 pages. Analytic charts allow you and your physicians to see at a glance your medication options—including new, promising, off-label and experimental all rated for clinical efficacy.

Free Updates for 1 Year
All 84 Outcomes
Top 200 Key Drugs and Biologics
Top 50 Key Therapies and Procedures
Detailed History Charts
Full Research Reference Details
Sample PDF Report on Psoriasis >>

Price:

$24.00 & Delivery via PDF download
updates for 1 year

Research Interface

Rapidly retrieve summaries of all the evidence for any disease in seconds. Save hours of search and analysis time. CureHunter is unlike any "search engine" you have ever used. Where standard "search engines" produce lists of links, CureHunter quantifies evidence, extracts it from the literature and calculates a result you can use to immediately facilitate evidence based decision making in Real Clinical Time.

Unlimited Disease, Drug and Therapy Search
2 clicks from Disease to Drug to Evidence
Trial References
All the Positive Outcomes
Detailed Relationship Timeline Charts
Full Article Reference Details
Includes Mobile Interface Subscription
One-click to FDA Products/Patents
Request Institution License Details >>

Price:

$490.00 access via web interface
1 year subscription

Proceed to Checkout >>

Mobile Interface

Retrieve summaries of all the evidence for any disease from your Mobile Phone or PDA. Accelerate decision making in the field. Speed up your study of new drug and disease domains. Refresh your knowledge on the road.

Access from any web enabled PDA or Phone
Trial references
All the Positive Outcomes
Drug and Therapy searches
Full Article Reference Details
Try Mobile Interface >>

Price:

$45.00 access via "curehunter.com/m"
1 year subscription

Proceed to Checkout >>