Abstract | BACKGROUND: While there is considerable epidemiologic evidence that cardiovascular risk factors increase risk of incident Alzheimer disease (AD), few studies have examined their effect on progression after an established AD diagnosis. OBJECTIVE: To examine the effect of vascular factors, and potential age modification, on rate of progression in a longitudinal study of incident dementia. METHODS: A total of 135 individuals with incident AD, identified in a population-based sample of elderly persons in Cache County, UT, were followed with in-home visits for a mean of 3.0 years (range: 0.8 to 9.5) and 2.1 follow-up visits (range: 1 to 5). The Clinical Dementia Rating (CDR) Scale and Mini-Mental State Examination (MMSE) were administered at each visit. Baseline vascular factors were determined by interview and physical examination. Generalized least-squares random-effects regression was performed with CDR Sum of Boxes (CDR-Sum) or MMSE as the outcome, and vascular index or individual vascular factors as independent variables. RESULTS: CONCLUSION:
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Authors | M M Mielke, P B Rosenberg, J Tschanz, L Cook, C Corcoran, K M Hayden, M Norton, P V Rabins, R C Green, K A Welsh-Bohmer, J C S Breitner, R Munger, C G Lyketsos |
Journal | Neurology
(Neurology)
Vol. 69
Issue 19
Pg. 1850-8
(Nov 06 2007)
ISSN: 1526-632X [Electronic] United States |
PMID | 17984453
(Publication Type: Journal Article, Research Support, N.I.H., Extramural)
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Chemical References |
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Topics |
- Age Distribution
- Aged
- Aged, 80 and over
- Alzheimer Disease
(epidemiology)
- Angina Pectoris
(epidemiology)
- Antihypertensive Agents
(therapeutic use)
- Atrial Fibrillation
(epidemiology)
- Cardiovascular Diseases
(epidemiology)
- Cohort Studies
- Comorbidity
- Coronary Artery Bypass
(statistics & numerical data)
- Diabetes Mellitus
(epidemiology)
- Disability Evaluation
- Disease Progression
- Female
- Humans
- Hypertension
(epidemiology)
- Incidence
- Longitudinal Studies
- Male
- Myocardial Infarction
(epidemiology)
- Neuropsychological Tests
- Predictive Value of Tests
- Survival Rate
- Utah
(epidemiology)
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