Atrial Fibrillation

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8946 relevant articles (857 outcomes, 1551 trials/studies) found for this Disease

Description: Abnormal cardiac rhythm that is characterized by rapid, uncoordinated firing of electrical impulses in the upper chambers of the heart (HEART ATRIA). In such case, blood cannot be effectively pumped into the lower chambers of the heart (HEART VENTRICLES). It is caused by abnormal impulse generation.

Also Known As:

Atrial Fibrillations; Auricular Fibrillations; Fibrillation, Atrial; Fibrillation, Auricular; Fibrillations, Atrial; Fibrillations, Auricular; Auricular Fibrillation

Relationship Network

Disease Context: Research Results

Cardiovascular Diseases: 20552

Heart Diseases: 13044

Cardiac Arrhythmias: 9023

Atrial Fibrillation: 8946

Signs and Symptoms Pathological Conditions

Pathologic Processes: 2442

Cardiac Arrhythmias: 9023

Atrial Fibrillation: 8946

Related Diseases

1.	Stroke (Strokes)
2.	Atrial Flutter (Flutter, Atrial)
3.	Tachycardia (Tachyarrhythmias)
4.	Heart Failure
5.	Supraventricular Tachycardia

Experts

1.	Lip, Gregory Y H: 55 articles (09/2008 - 05/2002)
2.	White, C Michael: 25 articles (04/2008 - 01/2002)
3.	Nattel, Stanley: 21 articles (07/2008 - 05/2002)
4.	Kluger, Jeffrey: 20 articles (04/2008 - 01/2002)
5.	Crijns, Harry J G M: 18 articles (01/2008 - 08/2002)
6.	Coleman, Craig I: 17 articles (04/2008 - 01/2004)
7.	Van Gelder, Isabelle C: 17 articles (04/2007 - 08/2002)
8.	Inoue, Hiroshi: 16 articles (04/2008 - 02/2002)
9.	Opolski, Grzegorz: 15 articles (11/2006 - 05/2002)
10.	Korantzopoulos, Panagiotis: 13 articles (10/2008 - 03/2003)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Atrial Fibrillation:

1.	Amiodarone (Amiodarona)FDA LinkGeneric 01/01/1985 - "Intravenous amiodarone appears as a highly effective medication in the conversion or control of new onset atrial fibrillation with fast ventricular response." 07/01/1980 - "Fifteen have been controlled with amiodarone, this treatment proving most effective in atrial fibrillation or flutter with or without pre-excitation. " 01/01/1991 - "Amiodarone (Cordarone) has been proven to be useful in the management of atrial fibrillation. " 07/01/2007 - "REASON FOR PERFORMING STUDY: Good results have been obtained with a human amiodarone (AD) i.v. protocol in horses with chronic atrial fibrillation (AF) and a pharmacokinetic study is required for a specific i.v. amiodarone treatment protocol for horses. " 06/26/2008 - "Amiodarone may prove beneficial in the primary prevention of atrial fibrillation, to convert fibrillation, to prevent recurrency, and finally, to reduce a fast ventricular rate that does not respond to standard therapy." Order ALL the reference details at left...
2.	Warfarin (Coumadin)FDA LinkGeneric 07/01/2005 - "Although highly effective in preventing thromboembolic events among patients with atrial fibrillation, warfarin therapy is limited by a multitude of potential problems. " 03/01/1992 - "Three randomised studies of primary prevention have shown a significant reduction of the embolic risk in non-valvular atrial fibrillation treated by warfarin compared to patients on placebo. " 10/01/2006 - "Under intense monitoring, adjusted-dose warfarin (INR 2.0 - 3.0) is effective and safe for the moderate to high risk nonvalvular atrial fibrillation patients." 04/01/2006 - "Under intensive monitoring, warfarin is effective and safe for the moderate to high risk atrial fibrillation patients." 05/01/2002 - "OBJECTIVES: To better understand the tradeoffs between the efficacy of anticoagulation with warfarin and its side effects in the oldest old with nonrheumatic atrial fibrillation (AF). " Order ALL the reference details at left...
3.	Propafenone (Rythmol)FDA LinkGeneric 06/01/1987 - "Furthermore, propafenone caused a marked decrease in peak ventricular rate during atrial fibrillation. " 03/01/1996 - "Furthermore, the percentage decrease of ventricular rate during atrial fibrillation was significantly greater in patients with propafenone (-25 +/- 4% versus -8 +/- 3%, P < 0.01). " 12/15/2002 - "We report a double-blind, multicenter, multinational, placebo-controlled, and well-controlled trial to prove that the sustained-release (SR) formulation of propafenone is superior to placebo in preventing symptoms of paroxysmal atrial fibrillation (AF). " 03/01/2000 - "Propafenone is an effective and safe antiarrhythmic drug for converting paroxysmal and/or recent-onset atrial fibrillation of various origins with a more limited efficacy in chronic atrial fibrillation." 01/01/1995 - "The two drugs were equally effective in converting postoperative atrial fibrillation and/or flutter after 24 h although propafenone was superior within the first hour." Order ALL the reference details at left...
4.	Aspirin (Acetylsalicylic Acid)FDA LinkGeneric 11/01/2000 - "METHODS: We performed a multicentric placebo-controlled double blind-trial to test the preventive efficacy against thromboembolic events of the addition of aspirin (A) (100 mg) or placebo (P) to anticoagulant treatment in patients with high-risk atrial fibrillation. " 03/01/1992 - "Only one study has shown a significant reduction of the embolic risk in patients under 75 years of age with non-valvular atrial fibrillation treated with 325 mg/day of aspirin. " 11/01/2000 - "BACKGROUND: A combination of low-dose aspirin (A) and anticoagulation (AC) may provide better protection against thromboembolic events compared with AC alone in high-risk patients with atrial fibrillation (AF). " 02/01/1992 - "The efficacy of aspirin has not been established in patients with atrial fibrillation who are greater than 75 years of age." 01/01/1991 - "Recently it was demonstrated that also aspirin seems effective in reducing incidence of thromboembolic complications in patients with chronic atrial fibrillation. " Order ALL the reference details at left...
5.	Sotalol (Sotalol Hydrochloride)FDA LinkGeneric 07/01/2000 - "Administration of intravenous sotalol was effective in preventing early reinitiation of atrial fibrillation in five of seven (71%) patients where pacing failed to suppress early reinitiation of atrial fibrillation. " 11/01/1997 - "Is oral sotalol effective in converting atrial fibrillation to sinus rhythm?" 04/01/1997 - "On subanalysis, sotalol was shown to be effective in the prophylaxis of both paroxysmal atrial fibrillation and paroxysmal reentrant arrhythmias. " 09/01/1993 - "A larger dose of sotalol (cumulative dose, 8 mg/kg) was uniformly effective in terminating atrial fibrillation and preventing its induction. " 02/01/1993 - "Sotalol was effective in reducing the incidence of atrial fibrillation. " Order ALL the reference details at left...
6.	Digoxin (Digitek)FDA LinkGeneric 10/01/2001 - "CONCLUSION: The first of the above adjustment methods would lead to good results if digoxin has not been prescriped in order to control the cardiac frequency in the setting of auricular fibrillation." 10/01/1992 - "In patients with atrial fibrillation digoxin is beneficial for ventricular rate control. " 04/01/1987 - "Study Objective: to determine whether digoxin is effective in converting atrial fibrillation of recent onset to normal sinus rhythm. " 12/16/2003 - "Digoxin is only effective for rate control at rest and therefore should only be used as a second-line agent for rate control in atrial fibrillation. " 01/01/1994 - "The use of digoxin remains a mainstay of treatment for rate control in atrial fibrillation. " Order ALL the reference details at left...
7.	Flecainide (Tambocor)FDA LinkGeneric 11/01/2004 - "REASONS FOR PERFORMING STUDY: It has been reported that i.v. flecainide has a high efficacy for the treatment of experimentally-induced acute atrial fibrillation (AF) in horses and that its use is associated with minimal toxic side effects. " 01/25/1996 - "Although both drugs were equally effective in adequately controlling recurrences of atrial fibrillation (difference, p = 0.282; not significant), fewer flecainide patients had to have their therapy discontinued due to adverse experiences (p = 0.012). " 07/01/1987 - "Flecainide therefore appears to be effective in reducing recent atrial fibrillation on a non-dilated atrium. " 11/01/2004 - "OBJECTIVES: The objectives were to study the efficacy of i.v. flecainide as a treatment for atrial fibrillation in horses with naturally-occurring AF. " 08/25/1988 - "This study was designed to assess the clinical efficacy of oral flecainide for the prevention of paroxysmal attacks of atrial fibrillation (AF). " Order ALL the reference details at left...
8.	Anti-Arrhythmia AgentsIBA 04/01/2006 - "Because presently available antiarrhythmic drugs are neither as highly efficacious nor as safe as desirable for the prevention of atrial fibrillation (AF), rate control-versus-rhythm control trials for the treatment of AF were evaluated. " 04/01/2007 - "The convenience to count with a safe and effective pharmacological wealth for atrial fibrillation treatment had conduced, in a way, to a deep depuration of the vast array of antiarrhythmic drugs, keeping only a very restricted number of compounds with a widely proved anti-atrial activity. " 07/01/1999 - "Antiarrhythmic drugs remain the mainstay of treatment of atrial fibrillation, but their potential proarrhythmic effects hamper their optimal use. " 10/01/2008 - "Drugs used for the prevention of atrial fibrillation are antiarrhythmic drugs of class IA and C, and type III. Drug combination acting through different electrophysiological channels and mechanisms may prove beneficial in the prevention of atrial fibrillation." 08/01/1999 - "Multivariate analysis demonstrated that only the presence of atrial fibrillation before ablation could independently predict improvement in general quality of life (p = 0.03), frequency of significant symptoms (p = 0.03), symptoms during attacks (p = 0.04), and decrease in the consumption of health care resources including antiarrhythmic drugs (p = 0.01), hospital admission (p = 0.02), and emergency room visits (p = 0.02). " Order ALL the reference details at left...
9.	Verapamil (Calan)FDA LinkGeneric 05/01/2001 - "CONCLUSIONS: In patients with chronic atrial fibrillation, clearance of oral, but not intravenous, S -verapamil and R -verapamil is significantly reduced with multiple doses compared with a single dose, thereby indicating predominant impairment of prehepatic rather than hepatic metabolism as the underlying mechanism. " 07/01/1998 - "The efficacy of sublingual verapamil (Verapabene, 40 mg) in acute control of high ventricular rate was assessed in 20 patients with chronic atrial fibrillation (AF) of ischemic origin (class NYHA II and III). " 07/01/1998 - "The efficacy of sublingual verapamil in controlling rapid ventricular rate in chronic atrial fibrillation." 04/01/1997 - "Despite a significant reduction in electrical remodeling, there was only a minimal reduction in inducibility of atrial fibrillation by verapamil (34% versus 39% in the control experiments, P = .03). " 05/01/2001 - "BACKGROUND: Racemic (R /S)- verapamil is widely used in the management of chronic atrial fibrillation. " Order ALL the reference details at left...
10.	Quinidine (Chinidin)FDA LinkGeneric 10/01/1990 - "Thus, quinidine treatment is more effective than no antiarrhythmic therapy in suppressing recurrences of atrial fibrillation but appears to be associated with increased total mortality." 09/01/2005 - "Quinidine is effective for treatment of atrial fibrillation (AF) in horses, but often accelerates ventricular response rate. " 12/01/2001 - "CONCLUSIONS: Oral quinidine was safe and effective in the conversion of persistent atrial fibrillation to sinus rhythm." 04/15/1984 - "Intravenous quinidine therapy was a safe and effective means of converting the acute onset of atrial fibrillation to normal sinus rhythm in anesthetized horses." 04/01/1976 - "Comparative efficacy of short-acting and long-acting quinidine for maintenance of sinus rhythm after electrical conversion of atrial fibrillation." Order ALL the reference details at left...

Therapies and Procedures

1.	Electric Countershock (Cardioversion) 10/01/1996 - "BACKGROUND: Previous studies in patients with atrial fibrillation undergoing intracardiac cardioversion have suggested that intracardiac cardioversion is highly effective and safe. " 02/20/2009 - "BACKGROUND: Electrical cardioversion (EC) remains the most effective treatment for the restoration of sinus rhythm in patients with atrial fibrillation (AF). " 04/14/2006 - "BACKGROUNDS: Cardioversion for atrial fibrillation (AF) is the most effective treatment for the restoration of sinus rhythm (SR). " 07/01/2005 - "CONCLUSION: For refractory atrial fibrillation to conventional cardioversion double sequential transthoracic shocks represents a safe and highly efficacious alternative and may have a general applicability." 02/01/1999 - "BACKGROUND AND OBJECTIVE: Although external electrical cardioversion is effective in most patients with atrial fibrillation, there are cases refractory to external cardioversion. " Order ALL the reference details at left...
2.	Coronary Artery Bypass (Coronary Artery Bypass Surgery) 01/01/2002 - "beta-adrenoceptor antagonists (b-blockers) are very effective in preventing atrial fibrillation after coronary artery bypass surgery. " 10/01/2003 - "OBJECTIVE: Despite improved perioperative management, atrial fibrillation (AF) after coronary artery bypass grafting (CABG) remains a relevant clinical problem, whose pathogenetic mechanisms remain incompletely explained. " 12/01/2000 - "Reduced incidence of atrial fibrillation with minimally invasive direct coronary artery bypass." 06/01/2009 - "The aim of this study was to evaluate the effect of preoperative statin therapy on new onset of postoperative atrial fibrillation in patients undergoing coronary artery bypass grafting. " 04/01/2009 - "This study aims to (1) identify the effect of atrial fibrillation on operative mortality and morbidity in patients undergoing isolated coronary artery bypass grafting and (2) identify the potential effect of atrial fibrillation on patients with decreased left ventricular ejection fraction (<or=40%). " Order ALL the reference details at left...
3.	Defibrillators (Defibrillator) 01/01/2006 - "Studies have investigated the effect of defibrillator paddle position on the efficacy of external electrocardioversion of atrial fibrillation, without agreeing upon an optimal placement. " 01/01/2000 - "The high prevalence of atrial fibrillation (AF) and its clinical complications, the poor efficacy of medical therapy for preventing recurrences, and dissatisfaction with alternative modes of therapy stimulated interest in implantable atrial and combined atrioventricular defibrillators. " 04/01/2006 - "INTRODUCTION: Implantable atrial defibrillators (IADs) have proved to be safe and effective in the management of atrial fibrillation. " 08/01/1999 - "Overall, the implantable atrial defibrillator Metrix is an effective and safe alternative in treating atrial fibrillation." 12/01/2003 - "However the DAVID trial results suggest that the dual chamber paced mode was not associated with improved quality of life or decreased frequency of hospitalization, inappropriate shocks from the defibrillator or atrial fibrillation. " Order ALL the reference details at left...
4.	Drug Therapy (Chemotherapy) 08/01/1999 - "Due to the limited efficacy of drug therapy in atrial fibrillation and the high rate of recurrence, strong efforts were made to find non-pharmacological strategies. " 01/01/2008 - "There is also evidence to suggest that atrial-fibrillation ablation is superior to drug therapy as first-line treatment. " 01/01/2003 - "In the elderly the mainstay of treatment of atrial fibrillation should utilize drug therapy. " 12/01/2005 - "[Relationship between efficacy of antiarrhythmic drug therapy and structural remodeling in patients with paroxysmal atrial fibrillation]" 09/18/2002 - "Improved suppression of recurrent atrial fibrillation with dual-site right atrial pacing and antiarrhythmic drug therapy." Order ALL the reference details at left...
5.	Electrodes (Electrode) 01/01/2004 - "The radiofrequency modified maze as an adjunctive procedure is safe and effective in eliminating atrial fibrillation using standard and cooling-tip ablation electrodes in combination with surgery for mitral valve disease." 06/01/1999 - "OBJECTIVES: We examined the feasibility and efficacy of using a single-pass, dual-electrode (Solo) lead for atrial fibrillation (AF) detection and defibrillation. " 10/01/2009 - "PURPOSE: The study aim was to validate the closed loop stimulation (CLS) vs. accelerometer (ACC) rate-responsive sensors with electrodes placed in the right ventricular high septal (RVHS) or right ventricular apical (RVA) lead positions in patients following 'ablate and pace' therapy for persistent atrial fibrillation. " 01/01/2006 - "BACKGROUND: In several studies, anterior-posterior electrode position has been demonstrated to be superior to anterior-lateral position for the termination of atrial fibrillation using monophasic waveform shocks, but data regarding biphasic shocks are still emerging. " 01/01/2006 - "OBJECTIVE: The aim of the study was to assess if the anterior-posterior electrode position for the conversion of atrial fibrillation using biphasic waveform shocks is more effective and needs less energy compared with the anterior-lateral position. " Order ALL the reference details at left...

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