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Resveratrol inhibits TNF-alpha-induced changes of adipokines in 3T3-L1 adipocytes.

Abstract
Tumor necrosis factor-alpha (TNF-alpha) is chronically elevated in adipose tissues of obese rodents and humans. Increased levels of TNF-alpha are implicated in the induction of atherogenic adipokines, such as plasminogen activator inhibitor -1 (PAI-1) and IL-6, and the inhibition of the anti-atherogenic adipokine, adiponectin. In this study, we investigated the effects of resveratrol on TNF-alpha-induced atherogenic changes of the adipokines in 3T3-L1 cells. Exposure to TNF-alpha for 24 h increased PAI-1 and IL-6 secretion and decreased adiponectin secretion. The mRNA expression of adipokines changed in parallel with mRNA expression. Resveratrol effectively reversed the secretion and mRNA expression of the atherogenic adipokines, PAI-1 and IL-6, induced by TNF-alpha. Decreased secretion levels and mRNA expression of adiponectin by TNF-alpha were also recovered by resveratrol treatment. Our results suggest that resveratrol may improve obesity-induced cardiovascular disease, particularly atherosclerosis, by attenuating the TNF-alpha-induced changes of adipokines.
AuthorsJiyun Ahn, Hyunjung Lee, Suna Kim, Taeyoul Ha
JournalBiochemical and biophysical research communications (Biochem Biophys Res Commun) Vol. 364 Issue 4 Pg. 972-7 (Dec 28 2007) ISSN: 1090-2104 [Electronic] United States
PMID17967414 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Adiponectin
  • Cytokines
  • Interleukin-6
  • Serpin E2
  • Serpine2 protein, mouse
  • Serpins
  • Stilbenes
  • Tumor Necrosis Factor-alpha
  • Vasodilator Agents
  • Resveratrol
Topics
  • 3T3-L1 Cells
  • Adipocytes (drug effects, metabolism)
  • Adiponectin (metabolism)
  • Animals
  • Cytokines (metabolism)
  • Dose-Response Relationship, Drug
  • Drug Interactions
  • Interleukin-6 (metabolism)
  • Mice
  • Resveratrol
  • Serpin E2
  • Serpins (metabolism)
  • Stilbenes (administration & dosage)
  • Tumor Necrosis Factor-alpha (administration & dosage)
  • Vasodilator Agents (administration & dosage)

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