Potential target of infliximab in autoimmune and inflammatory diseases.

Abstract

Tumour necrosis factor-alpha (TNF-alpha) is a pro-inflammatory cytokine produced by many cell types (blood monocytes, macrophages, mast cells and endothelial cells), that play a key role in the pathogenesis of multiple autoimmune and nonautoimmune disorders. A number of large placebo-controlled trials have shown that infliximab, a chimeric monoclonal antibody against TNF-alpha, is effective and well tolerated in patients with Crohn's disease, rheumatoid arthritis and spondiloarthritides and has become a widely used treatment for these diseases. Preliminary data suggest that several forms of vasculitis appear responsive to TNF antagonists: Behçet's disease, Churg-Strauss vasculitis, polyarteritis nodosa, and giant cell arteritis, among others. Wegener's granulomatosis and sarcoidosis have been shown to improve with infliximab. Polymyositis/dermatomyositis may also be responsive to TNF blockade. TNF likely plays little role in Sjögren's syndrome as evidenced by the lack of efficacy of TNF antagonists. There is a rationale for using TNF blockade even in systemic lupus erythematosus, a prototype of autoantibody-mediated disease, and a pilot study seems to confirm this potential effective approach. A number of other more rare disorders also may be responsive to TNF blockade. We here review the current and prospective roles of infliximab in the treatment of autoimmune diseases and other conditions.

• Authors: Fabiola Atzeni, Andrea Doria, Mario Carrabba, Maurizio Turiel, Piercarlo Sarzi-Puttini
• Journal: Autoimmunity reviews (Autoimmun Rev) Vol. 6 Issue 8 Pg. 529-36 (Sep 2007) ISSN: 1568-9972 [Print] Netherlands
• PMID: 17854744 (Publication Type: Journal Article, Review)

Chemical References

• Anti-Inflammatory Agents
• Antibodies, Monoclonal
• Tumor Necrosis Factor-alpha
• Infliximab

Topics

• Anti-Inflammatory Agents (immunology, pharmacology, therapeutic use)
• Antibodies, Monoclonal (immunology, pharmacology, therapeutic use)
• Autoimmune Diseases (drug therapy, immunology)
• Humans
• Immune System Diseases (drug therapy, immunology)
• Inflammation (drug therapy, immunology)
• Infliximab
• Tumor Necrosis Factor-alpha (antagonists & inhibitors, immunology)