Abstract | OBJECTIVE: BACKGROUND: METHODS:
IL-6 serum concentrations were determined at baseline and follow-up in 47 consecutive ICD-patients with CAD and idiopathic dilated cardiomyopathy (IDC). Data were prospectively correlated with VT/VF-incidence. RESULTS: Thirty-six patients (76.6%) suffered from CAD and 11 (23.4%) from IDC. Mean serum concentrations of IL-6 at baseline and at 9 months follow-up were 6.12+/-4.98 and 4.63+/-6.97. 88 spontaneous VT/VF-events occurred in 13/47 patients (27.7%). Patients with VT/VF had significantly higher IL-6 levels as compared to patients without VT/VF (8.96+/-5.97 vs. 5.04+/-4.16pg/ml at baseline (p =0.03), 7.8+/-4.88 vs. 3.42+/-6.32pg/ml at follow-up (p =0.01)). CONCLUSIONS: Elevated IL-6 serum concentrations were prospectively associated with an increased risk of spontaneous VT/VF-events in ICD-patients with CAD or IDC. These preliminary findings support a possible association of proinflammatory activity and an increased susceptibility to spontaneous VT/VF-events.
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Authors | Florian Streitner, Juergen Kuschyk, Christian Veltmann, Martina Brueckmann, Ines Streitner, Joachim Brade, Michael Neumaier, Thomas Bertsch, Burghard Schumacher, Martin Borggrefe, Christian Wolpert |
Journal | Cytokine
(Cytokine)
Vol. 40
Issue 1
Pg. 30-4
(Oct 2007)
ISSN: 1096-0023 [Electronic] England |
PMID | 17851087
(Publication Type: Journal Article)
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Chemical References |
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Topics |
- Aged
- Cardiomyopathy, Dilated
(blood, complications, therapy)
- Cohort Studies
- Coronary Artery Disease
(blood, complications, therapy)
- Defibrillators, Implantable
- Female
- Follow-Up Studies
- Humans
- Interleukin-6
(biosynthesis, blood)
- Male
- Pilot Projects
- Prospective Studies
- Risk Assessment
- Tachycardia, Ventricular
(blood, etiology)
- Ventricular Fibrillation
(blood, etiology)
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