Thrombin receptor agonist Peptide immobilized in microspheres stimulates reparative processes in rats with gastric ulcer.

Abstract

The effect of synthetic thrombin receptor (PAR1) agonist peptide encapsulated in microspheres made of lactic and glycolic acid copolymer on tissue reparation was studied in rats with acetate-induced ulcer. PAR1 agonist peptide was immobilized in biodegraded lactic and glycolic acid microspheres by double emulgation, the kinetics of peptide release was analyzed, and the dynamics of ulcer healing was studied in experimental (administration of microspheres with the peptide into the stomach) and two control groups (administration of saline or spheres without peptide). Thrombin receptor agonist peptide gradually released from lactic and glycolic acid microspheres into the stomach shortened the inflammation phase and shifted the proliferation phase to the earlier period, thus accelerating healing of experimental ulcers in rats.

• Authors: A V Rusanova, A M Makarova, S M Strukova, E A Markvicheva, L R Gorbachyova, K S Stashevskaya, T V Vasil'eva, E I Sidorova, Zh D Bespalova, Ch Grandfils
• Journal: Bulletin of experimental biology and medicine (Bull Exp Biol Med) Vol. 142 Issue 1 Pg. 35-8 (Jul 2006) ISSN: 0007-4888 [Print] United States
• PMID: 17369897 (Publication Type: Comparative Study, Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Acetates
• Glycolates
• Peptide Fragments
• Receptor, PAR-1
• thrombin receptor peptide (42-47)
• glycolic acid
• Lactic Acid

Topics

• Acetates (toxicity)
• Animals
• Case-Control Studies
• Glycolates
• Kinetics
• Lactic Acid
• Microspheres
• Peptide Fragments (metabolism, pharmacology, therapeutic use)
• Rats
• Receptor, PAR-1 (agonists)
• Stomach Ulcer (chemically induced, drug therapy, pathology)
• Wound Healing (drug effects)