Abstract | OBJECTIVE: METHODS: C57BL/KsJ-db/db (db/db) diabetic obese mice and C57BL/KsJ-db/+m (db/+m) control mice were fed a diet containing 0% w/w CLPr (0% CLPr), 0.5% w/w CLPr (0.5% CLPr), or 1.0% w/w CLPr (1.0% CLPr) from age 3 wk to age 6 wk. Levels of blood glucose were measured at 4 and 5 wk of age. The animals were sacrificed and the levels of blood glucose and fructosamine were measured at 6 wk of age. RESULTS: The levels of blood glucose and fructosamine were higher in the db/db mice than in the db/+m mice fed a diet containing 0%, 0.5%, or 1.0% CLPr. In the db/+m mice, the levels of blood glucose or fructosamine were not significantly different across animals fed 0% CLPr, 0.5% CLPr, and 1.0% CLPr. In the db/db mice, however, a diet containing 0.5% or 1.0% CLPr decreased the levels of blood glucose and fructosamine compared with that containing 0% CLPr without significant effects on body weights or food consumption. CONCLUSION: Dietary supplementation with CLPr can dose-dependently prevent the development of hyperglycemia in diabetic obese mice. The dietary intake of food or drinks produced from cacao beans might be beneficial in preventing the onset of type 2 diabetes mellitus.
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Authors | Makoto Tomaru, Hirohisa Takano, Naomi Osakabe, Akiko Yasuda, Ken-ichiro Inoue, Rie Yanagisawa, Tsuneto Ohwatari, Hiroshi Uematsu |
Journal | Nutrition (Burbank, Los Angeles County, Calif.)
(Nutrition)
Vol. 23
Issue 4
Pg. 351-5
(Apr 2007)
ISSN: 0899-9007 [Print] United States |
PMID | 17350804
(Publication Type: Journal Article)
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Chemical References |
- Blood Glucose
- Hypoglycemic Agents
- Proanthocyanidins
- Fructosamine
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Topics |
- Aging
(physiology)
- Animals
- Blood Glucose
(drug effects, metabolism)
- Body Weight
(drug effects)
- Cacao
(chemistry)
- Diabetes Mellitus, Experimental
(prevention & control)
- Dietary Supplements
- Dose-Response Relationship, Drug
- Fructosamine
(pharmacology)
- Hyperglycemia
(prevention & control)
- Hypoglycemic Agents
(pharmacology)
- Mice
- Mice, Inbred C57BL
- Mice, Obese
- Obesity
(complications)
- Postprandial Period
- Proanthocyanidins
(pharmacology)
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