Abstract | PURPOSE: METHODS: We performed a retrospective survey with nine German centers and evaluated 72 patients treated from 1993 to 2005. RESULTS: The objective response rate in stage III melanoma (n = 39) was 62%. In contrast, only 9% objective responses were observed in 33 stage IV patients. Interestingly, more than half of patients with objective remissions remained progression-free for more than 1 year irrespective of the stage of disease. CONCLUSIONS: Epifocal DNCB combined with DTIC is effective in patients with regionally metastasized melanoma not amenable to surgery or isolated limb perfusion, whereas in stage IV disease in spite of few durable remissions the addition of DNCB does not improve the therapeutic efficacy of DTIC.
|
Authors | P Terheyden, A-K Kortüm, H-J Schulze, B Durani, R Remling, C Mauch, V Junghans, D Schadendorf, U Beiteke, M Jünger, J C Becker, E-B Bröcker |
Journal | Journal of cancer research and clinical oncology
(J Cancer Res Clin Oncol)
Vol. 133
Issue 7
Pg. 437-44
(Jul 2007)
ISSN: 0171-5216 [Print] Germany |
PMID | 17334785
(Publication Type: Journal Article)
|
Chemical References |
- Dinitrochlorobenzene
- Irritants
- Dacarbazine
|
Topics |
- Adult
- Aged
- Antineoplastic Combined Chemotherapy Protocols
(therapeutic use)
- Dacarbazine
(administration & dosage)
- Dinitrochlorobenzene
(administration & dosage)
- Disease-Free Survival
- Female
- Germany
- Humans
- Irritants
(administration & dosage)
- Male
- Melanoma
- Middle Aged
- Neoplasm Metastasis
- Neoplasm Staging
- Prognosis
- Retrospective Studies
- Skin Neoplasms
(drug therapy)
- Survival Analysis
|